Iimveliso

I-europium(III) kunye ne-terbium(III) iikhompleksi, ezizezi [Eu(dpq)(DMF)2(NO3)3] (1), [Eu(dppz)2(NO3)3] (2), [Tb(dpq) )(DMF)2Cl3] (3), kunye [Tb(dppz)(DMF)2Cl3] (4), apho i-dipyrido[3,2-d:2',3'-f]quinoxaline (dpq ku-1 no-3) , i-dipyrido [3,2-a: 2',3'-c] phenazine (dppz kwi-2 kunye ne-4) kunye ne-N, N'-dimethylformamide (DMF) ziye zahlukaniswa, zibonakaliswe kwiinkcukacha zabo ze-physicochemical, izifundo ze-luminescence kunye nokusebenzisana kwazo. kunye ne-DNA, i-serum albumin protein kunye ne-photo-induced DNA cleavage activity iyaphononongwa.Izakhiwo ze-crystal ze-X-ray ze-complexes 1-4 zibonisa i-discrete mononuclear Ln (3+)-based based structures.I-Eu(3+) kwi- [Eu(dpq)(DMF)2(NO3)3] (1) kunye ne [Eu(dppz)2(NO3)3] (2) njenge [Eu(dppz)2(NO3)3) ] · dppz (2a) ithatha ishumi elilungelelanisiweyo lwesakhiwo sedodekahedron ene-bidentate N,N-donor dpq ligand, DMF ezimbini kunye neeanion ezintathu ze-NO3(-) kwi-1 kunye ne-bidentate ezimbini ze-N,N-donor dppz ligand kunye ne-NO3 ezintathu( -) i-anions kwi-2. Ii-Complex 3 kunye ne-4 zibonisa isakhiwo se-octahedron esilungelelanisiweyo se-mono-capped apho i-Tb (3+) iqulethe i-bidentate dpq / dppz ligands, i-DMF ezimbini kunye nee-anion ezintathu ze-Cl (-).Iikhompleksi zikhanya kakhulu kwindalo ebonisa ukhutshelo olusebenzayo lwefoto-imincili yamandla ukusuka kwi-eriyali ye-dpq/dppz ukuya kwi-Ln(3+) ukuvelisa iimeko ezimincili ezihlala ixesha elide kuphawu f → f iinguqu.Imbonakalo yokukhanya esonjululwe lixesha yekhompleksi 1-4 ibonisa amabhanti okukhutshwa emxinwa okubalelwa ku (5)D0 → (7)F(J) kunye (5)D4 → (7)F(J) ff iinguqulelo ze-Eu(3) +) kunye ne-Tb(3+) ion ngokulandelelanayo.Inani leemolekyuli zamanzi zangaphakathi (q) zagqitywa ukusuka kwimilinganiselo yokuphila kwe-luminescence kwi-H2O kunye ne-D2O eqinisekisa ukuphendula kwe-ligand-exchange ngamanzi kwisisombululo.I-complexes ibonisa ukuthambekela okubophelelayo okubalulekileyo kwi-CT-DNA enika amaxabiso ahlala ebophelelayo kuluhlu lwe-1.0 × 10 (4) -6.1 × 10 (4) M (-1) ngomyalelo 2, 4 (dppz) > 1, 3 (dpq).Idatha ebophelelayo ye-DNA icebisa ukuba i-DNA groove ibopheleleke kunye nenxalenye yendalo yonxulumano lwezakhiwo.Zonke iikhompleksi nazo zibonisa ukuthambekela kokubophelela (K(BSA) ~ 10(5) M(-1)) kwiprotein ye-bovine serum albumin (BSA).Ukuqina kweebhendi ze-spectral ze-luminescence ze-luminescence ziphucula kakhulu ngokunyuka kwe-DNA yoxinaniso kwindawo ye-aqueous buffer medium ngenxa yokufuduswa kwamanzi abophekileyo xa usebenzisana ne-DNA, ngaloo ndlela kuncitshiswe ukucinywa kwe-non-radiative nge-oscillator ye-OH.I-Complexes 1-4 ngokufanelekileyo iqhekeza i-supercoiled (SC) ds-DNA kwifomu yayo ye-nicked setyhula (NC) ekuvezweni kwi-UV-A ukukhanya kwe-365 nm ngokusekwa kwe-singlett oxygen ((1)O2) kunye ne-hydroxyl radicals (HO˙) njengoko Iindidi zeoksijini ezisebenzayo kugxininiso lwe-micromolar phantsi kweemeko zomzimba.