Metronidazole Cas: 443-48-1
| Inombolo Yekhathalogu | XD91888 |
| Igama lemveliso | Metronidazole |
| CAS | 443-48-1 |
| Ifomu yemolekyulila | C6H9N3O3 |
| Ubunzima beMolekyuli | 171.15 |
| Iinkcukacha zokuGcina | 2-8°C |
| IKhowudi yoMrhumo eHarmonized | 29332990 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe wekristale |
| uAsay | 99% imizuzu |
| Indawo yokunyibilika | 159-161 °C (isibane.) |
| Indawo yokubilisa | 301.12°C (uqikelelo olurhabaxa) |
| ukuxinana | 1.3994 (uqikelelo olurhabaxa) |
| isalathiso se-refractive | 1.5800 (uqikelelo) |
| Fp | 9℃ |
| ukunyibilika | iacetic acid: 0.1 M, ecacileyo, etyheli kancinci |
| pka | pKa 2.62(H2O,t =25±0.2,Iundefined) (Akuqinisekanga) |
| Ukunyibilika kwamanzi | <0.1 g/100 mL ku-20 ºC |
I-Metronidazole lichiza elikhethiweyo le-amebiases, i-vaginal trichomonasis kunye ne-trichlomonadic urethritis emadodeni, i-lambliosis, i-amebic dysentery, kunye nosulelo lwe-anaerobic olubangelwa yi-microorganisms evakalelwa kwiyeza.Izithethantonye zeli chiza yi-flagyl, protostat, trichopol, kunye ne-vagimid.
I-Metronidazole ifumaneka njengamalungiselelo omlomo, e-intravaginal, e-topical, kunye ne-parenteral.Iveliswa ziinkampani ezininzi, kodwa ifumaneka kuphela ngomyalelo kagqirha.Ukuvezwa kokusingqongileyo ngokungeyomfuneko akunakwenzeka, kwaye ukuba kuyenzeka, akunakwenzeka kakhulu ukuba kubangele ubuthi.
Isetyenziswa njenge-antibacterial kunyango lwe-rosacea.Antiprotozoal (trichomonas).I-carcinogen enokubakho yomntu.
I-Metronidazole, i-antibiotic kunye ne-antiprotozoal agent.Isetyenziselwa ikakhulu ukunyanga okanye ukuthintela usulelo lwenkqubo okanye lwengingqi olubangelwa yibhaktheriya ye-anaerobic, njengosulelo lwebhaktiriya ye-anaerobic kwisigxina sesisu, umgudu wokugaya, inkqubo yokuzala yabasetyhini, indlela yokuphefumla ephantsi, ulusu kunye nezicubu ezithambileyo, amathambo kunye namalungu, njl njl. , ukwasulelwa yimeningeal, kunye nokudumba kwesisu okubangelwa kukusetyenziswa kwamayeza okubulala iintsholongwane nako kuyasebenza.I-Tetanus isoloko inyangwa nge-tetanus antitoxin (TAT).Ingasetyenziselwa usulelo lwe-anaerobic ngomlomo.Ngo-Oktobha 27, i-2017, uluhlu lwe-carcinogens olupapashwe yi-World Health Organization ye-International Agency ye-Arhente yoPhando lweCancer yahlelwa kwangaphambili ukuba ibhekiselele, kwaye i-metronidazole ifakwe kuluhlu lweklasi ye-2B ye-carcinogens.NgoJanuwari 2020, i-metronidazole yakhethwa kwibhetshi yesibini yoluhlu lwesizwe lokuthengwa kweziyobisi olukwindawo enye.
I-Metronidazole yeyona arhente isebenzayo ekhoyo kunyango lwabantu abanazo zonke iintlobo ze-amebiasis, mhlawumbi ngaphandle komntu ongenazimpawu kodwa oqhubeka ekhupha ama-cysts.Loo meko ifuna i-intraluminal amebicide esebenzayo, njenge-diloxanide furoate, paromomycin sulfate, okanye i-dioodohydroxyquin.I-Metronidazole iyasebenza ngokuchasene ne-cysts yamathumbu kunye ne-extraintestinal kunye ne-trophozoites.
Nangona i-quinacrine hydrochloride isetyenziselwa unyango lwe-giardiasis, oogqirha abaninzi bakhetha i-metronidazole.I-Furazolidone yenye ukhetho.
I-Metronidazole lichiza elikhethiweyo eYurophu losulelo lwebhaktiriya ye-anaerobic;inkxalabo malunga ne-carcinogenicity enokubakho kuye kwakhokelela ekubeni kulumke ekusetyenzisweni kwayo e-United States.Kutsha nje kufunyanwe ukuba iyasebenza ekuphatheni i-D. medinensis (i-Guinea worm) usulelo kunye ne-Helicobacter pylori.
Ikwasetyenziswa kwi-acne rosacea, balantidiasis kunye nosulelo lwe-Guinea worm.Usulelo lwe-T. vaginalis oluxhathisayo kwidosi eqhelekileyo lufuna unyango olukhethekileyo.
