N- (2-Acetamide) iminodiacetic acid Cas: 26239-55-4 99% umgubo omhlophe
| Inombolo Yekhathalogu | XD90194 |
| Igama lemveliso | I-ADA (N-(-2-Acetamido)iminodiacetic acid) |
| CAS | 26239-55-4 |
| Ifomula yeemolekyuli | I-C6H10N2O5 |
| Ubunzima beMolekyuli | 190.15 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29241900 |
Ukucaciswa kweMveliso
| Fe | <5ppm |
| Pb | <5ppm |
| Ilahleko ekomisweni | <0.5% |
| Uthuthu olufakwe emanzini | <0.1% |
| Imbonakalo | Umgubo omhlophe |
| Ezinye izinyibilikisi | Akukho nanye |
| Ixesha lokuchithwa (i-9g kwi-91ml 1M NaOH, i-Magnetic Striring) | <1min |
| I-A300 ( 9% kwi-1 M NaOH) | <0.08% |
| Inani leendawo zokuphela Kuqatshelwe kwigophe letitration | Zimbini kuphela |
| Uluhlu lwe-pH oluchaza i-Titration Second Endpoint | 9.1 - 10.1 |
| Ukunyibilika (9% kwi-1M NaOH) | Icacile kwaye ayinaMbala |
| Umhla wokwenziwa | |
| Amanzi KF | <1% |
| Uvavanyo (Titration) kwisiseko esomileyo | >99.0% |
| I-infrared | Iyahambelana |
I-nucleoside adenosine isebenza kwiinkqubo ze-nervous kunye ne-cardiovascular ngokusebenzisa i-A2A receptor (A2AR).Ukuphendula kwinqanaba le-oksijini kwizicubu, i-adenosine i-plasma concentration ilawulwa ngokukodwa ngokusebenzisa i-CD73 kunye nokuthotywa kwayo nge-adenosine deaminase (ADA).I-CD26 ye-cell-surface endopeptidase ilawula ukuxinwa kwe-vasoactive kunye ne-antioxidant peptides kwaye ngoko ilawula ukunikezelwa kwe-oksijini kwiithishu kunye nempendulo yoxinzelelo lwe-oxidative.Nangona ukugqithiswa kwe-adenosine, i-CD73, i-ADA, i-A2AR, kunye ne-CD26 ekuphenduleni i-hypoxia ibhalwe kakuhle, imiphumo ye-hyperoxic kunye neemeko ze-hyperbaric kwezi zinto zifanelwe ukuqwalaselwa ngakumbi.Iigundane kunye ne-murine Chem-3 cell line echaza i-A2AR yavezwa kwi-0.21 bar O2, i-0.79 bar N2 (imeko zomhlaba; normoxia);1 ibha O2 (hyperoxia);I-2 bar O2 (i-hyperbaric hyperoxia);I-0.21 ibha ye-O2, i-1.79 bar N2 (hyperbaria).I-Adenosine i-plasma concentration, i-CD73, i-ADA, i-A2AR ibonakaliso, kunye nomsebenzi we-CD26 zibhekiswe kwi-vivo, kunye nokuveliswa kwe-cAMP kubhekiswe kwi-cellulo.Kwiimeko ze-vivo, i-1) i-hyperoxia yehla i-adenosine plasma level kunye ne-T cell surface CD26 umsebenzi, ngelixa ikhulise i-CD73 ibonakaliso kunye nenqanaba le-ADA;2) i-hyperbaric hyperoxia ithambekele ekukhuliseni umkhwa;kunye ne-3) i-hyperbaria yodwa yayingenayo impembelelo ebalulekileyo kule parameters.Kwingqondo kunye ne-cellulo, i-1) i-hyperoxia iyancipha intetho ye-A2AR;2) i-hyperbaric hyperoxia yandisa umkhwa;kunye ne-3) i-hyperbaria yodwa ibonise umphumo onamandla kakhulu.Sifumene ipateni efanayo malunga ne-A2AR mRNA synthesis kwingqondo kunye nemveliso ye-cAMP kwiiseli ze-Chem-3.Ngaloo ndlela inqanaba eliphezulu le-oksijini lithande ukunciphisa indlela ye-adenosinergic kunye nomsebenzi we-CD26.I-Hyperbaria yodwa ichaphazele kuphela ukubonakaliswa kwe-A2AR kunye nokuveliswa kwe-camp.Sixoxa ngendlela ezo ndlela ezibangelwa yi-hyperoxygenation zinokukhawulelana ngayo, nge-vasoconstriction, ukunikezelwa kwe-oksijini kwizicubu kunye nokuveliswa kweentlobo ze-oksijini ezisebenzayo.
