Iimveliso

N-[(2'-cyano [1,1'biphenyl] -4-yl) methyl]-methyl ester L-valine monohydrochloride liyeza elisetyenziswa ngokuqhelekileyo kunyango lwe-hypertension, eyaziwa nangokuthi uxinzelelo lwegazi oluphezulu.Kukwiklasi yeziyobisi ezibizwa ngokuba yi-angiotensin-converting enzyme (ACE) inhibitors.Uxinzelelo lwegazi oluphezulu yimeko eqhelekileyo enokunyusa umngcipheko weengxaki zempilo ezininzi, kubandakanywa nesifo senhliziyo, isifo sohlangothi kunye nokulimala kwezintso.I-ACE inhibitors, njenge-N-[(2'-cyano [1,1'biphenyl] -4-yl) methyl]-methyl ester L-valine monohydrochloride, ihlala imiselwe ukunceda ukunciphisa uxinzelelo lwegazi kunye nokunciphisa uxinzelelo lwentliziyo kunye imithambo yegazi.Inkqubo ephambili yesenzo se-N-[(2'-cyano [1,1'biphenyl] -4-yl) methyl] -methyl ester L-valine monohydrochloride inqanda umsebenzi we-angiotensin-converting enzyme (ACE) ).I-ACE inoxanduva lokuguqula i-angiotensin I kwi-angiotensin II, i-vasoconstrictor enamandla, eyenza iyancipha imithwalo yegazi kwaye inyuse uxinzelelo lwegazi.Ngokuthintela i-ACE, eli liyeza linceda ukukhusela ukubunjwa kwe-angiotensin II, ekhokelela kwi-vasodilation (ukwandiswa kwemithambo yegazi) kunye nokunciphisa uxinzelelo lwegazi.N-[(2'-cyano [1,1'biphenyl] -4-yl) )methyl]-methyl ester L-valine monohydrochloride idla ngokuthathwa ngomlomo, rhoqo njengedosi kanye ngemini.Idosi ethile kunye nezihlandlo zolawulo ziya kuxhomekeka kwizinto ezahlukeneyo, kubandakanywa ubunzima boxinzelelo lwegazi kunye nempendulo yomntu kunyango.Eli liyeza linokusetyenziswa lodwa okanye lidityaniswe namanye amachiza alwa noxinzelelo lwegazi ukufikelela kulawulo olululo loxinzelelo lwegazi.Kubalulekile ukuqaphela ukuba N-[(2'-cyano [1,1'biphenyl] -4-yl)methyl]-methyl I-ester L-valine monohydrochloride inokubangela iziphumo ebezingalindelekanga ezithile kwabanye abantu.Iziphumo ebezingalindelekanga eziqhelekileyo ziquka isiyezi, intloko ebuhlungu, ukukhohlela okomileyo, kunye nokudinwa.Ukuba ezi ziphumo bezingalindelekanga ziyaqhubeka okanye ziyakhathaza, kuyacetyiswa ukuba udibane nengcali yezempilo.Kwiimeko ezinqabileyo, iziphumo ezibi kakhulu zinokuthi zenzeke, ezifana nokungahambi kakuhle, iingxaki zezintso, okanye i-angioedema (ukuvuvukala okukhulu kobuso, imilebe, umqala okanye ulwimi).Ukuba kukho naziphi na iziphumo ezibi kakhulu ezifunyenweyo, kufuneka kufunwe unyango olukhawulezileyo.Ngaphambi kokuqala i-N-[(2'-cyano[1,1'biphenyl] -4-yl)methyl]-methyl ester L-valine monohydrochloride, kubalulekile. ukuveza naziphi na iimeko zonyango ezikhoyo okanye ukungezwani nomzimba kugqirha ochazayo.Amayeza asenokungafaneleki kubantu abanesifo sezintso, isifo sesibindi, okanye isifo senhliziyo, njengoko sinokuthi sibe mandundu ngakumbi ezi meko. Isishwankathelo, N-[(2'-cyano[1,1'biphenyl]-4) -yl) methyl] -methyl ester L-valine monohydrochloride yi-ACE inhibitor esetyenziselwa ukunyanga uxinzelelo lwegazi.Ngokuthintela i-ACE, inceda ekwandiseni imithambo yegazi kunye nokunciphisa uxinzelelo lwegazi.Ukubambelela kwiidosi ezimiselweyo, ukulandelela rhoqo kunye nabasebenzi bezempilo, kunye nokubeka iliso kwiziphumo ebezingalindelekanga ezinokubakho zibalulekile kusetyenziso olukhuselekileyo nolusebenzayo lweli yeza.Kwakhona kubalulekile ukugcina indlela yokuphila enempilo, kuquka ukuzivocavoca rhoqo, ukutya okunokulinganisela, kunye nokulawula uxinzelelo, ukuxhasa ngakumbi ukulawula uxinzelelo lwegazi.