Iimveliso

Ukuncipha kwesisindo esitsha kunye neziyobisi zokunciphisa i-lipid: I-Orlistat luhlobo olutsha lokunciphisa umzimba kunye neyeza lokunciphisa i-lipid ngoku eyaziwa ngamazwe ngamazwe.Ngokuthengiswa konyaka kwe-US $ 538 yezigidi, i-orlistat okwangoku ithatha i-80% yemarike yokulahlekelwa kwesisindo emhlabeni jikelele, kunye nokuthengiswa konyaka eHong Kong, i-China yodwa ifikelela kwi-US $ 80 yezigidi.Okwangoku kuphela kwechiza le-OTC lokunciphisa ubunzima emhlabeni.Abantu abangaphezu kwe-40,000,000 emhlabeni jikelele bayithathile kwaye balahlekelwa ngempumelelo ubunzima.Okwangoku iyona mveliso yokulahleka kwesisindo ethengiswa kakhulu.Isebenza kakuhle ekulahlekeni kwesisindo.I-Orlistat inamandla kwaye ithatha ixesha elide i-gastrointestinal lipase inhibitor.Ngokuthintela ngokuthe ngqo ukufunxa umzimba kwamafutha ekudleni, emva kokuba ukutya kweekhalori kunye namafutha kungaphantsi kokusetyenziswa, amanqatha omzimba ayancipha ngokwemvelo, ukuze afezekise injongo yokunciphisa umzimba.Kukhuselekile ukunciphisa umzimba, izithako ezisebenzayo azifaki ukujikeleza kwegazi, kwaye musa ukwenza inkqubo ye-nervous central.

I-Orlistat yinto esebenza ixesha elide kwaye inamandla athile e-gastrointestinal lipase inhibitor, i-white or off-white powder kwiqondo lokushisa, i-soluble emanzini, i-soluble kwi-chloroform, kwaye i-soluble kalula kwi-ethanol.Iindawo ezisebenzayo ze-serine ze-gastric lipase kunye ne-pancreatic lipase zenza i-covalent bonds ukuze zingasebenzi i-enzymes.Amafutha ekutyeni awakwazi ukubola kwi-fatty acids yamahhala kunye ne-monoacylglycerols, ngoko ke amanqatha awakwazi ukufunxwa kwaye asetyenziswe, ngaloo ndlela ukunciphisa i-calories yokutya kunye nokulawula ubunzima bomzimba.Eli yeza alifuni ukufunxa inkqubo yokusebenza.Kwiidosi eziqhelekileyo, ukufunxa kwamafutha kunokuthintelwa ngama-30%.Ayifane ifunwe emva kokulawulwa komlomo, kwaye inokuthi ingasebenzi nge-metabolism kwi-intestinal tract.Indawo ye-metabolism iseludongeni lwesisu, kwaye ukuphelisa isiqingatha-ubomi malunga ne-14 ukuya kwii-19 iiyure.Ngokumalunga ne-97% yale mveliso ikhutshwe ngendle, apho i-83% ikhutshwe kwimo yayo yangaphambili.

Ingasetyenziselwa iklinikhi ekutyebeni kunye ne-hyperlipidemia.Kwiimeko eziqhelekileyo, umthamo we-120 mg ungathathwa ngomlomo, kathathu ngosuku, ngokutya okanye i-1 iyure emva kokutya.Ubunzima bunokuqala ukuhla emva kweeveki ezi-2 zokuthatha ichiza.Inokuthi ithathwe ngokuqhubekayo kwiinyanga ezi-6 ukuya kwezi-12.Ukuba i-dose inyuswe ngaphezu kwe-400 mg ngosuku, umphumo wayo awuyi kuphinda uphuculwe.