Isisombululo sePoly-L-lysine ( 0.1%) Cas: 25988-63-0
| Inombolo Yekhathalogu | XD90306 |
| Igama lemveliso | Isisombululo sePoly-L-lysine ( 0.1%) |
| CAS | 25988-63-0 |
| Ifomula yeemolekyuli | C18H38N6O4 |
| Ubunzima beMolekyuli | 402.532124042511 |
| Iinkcukacha zokuGcina | 2-8°C |
Ukucaciswa kweMveliso
| Isivavanyi | 0.1% |
| Imbonakalo | Ulwelo olungenambala |
Ukuguqulwa kwe-eucine-rich repeat kinase 2 (LRRK2) ngoyena nobangela owaziwayo we-Parkinson's disease (PD).Iimpawu zeklinikhi ze-LRRK2 PD azibonakali kwi-idiopathic PD, kunye nokuqokelela kwe-α-synuclein kunye / okanye i-tau kunye / okanye i-ubiquitin kwi-intraneuronal aggregates.Oku kuphakamisa ukuba i-LRRK2 ngundoqo ekuqondeni i-aetiology ye-disorder.Nangona ukulahlekelwa komsebenzi kungabonakali njengendlela ebangela iPD kwizigulane ze-LRRK2, akucaci ukuba le proteni idibanisa njani ubuthi.Kule sifundo, sixela ukuba i-LRRK2 i-overexpression kwiiseli kunye ne-vivo iphazamisa umsebenzi wendlela ye-ubiquitin-proteasome, kwaye le nto ibangela ukuqokelela kwee-substrates ezahlukeneyo kunye ne-LRRK2 overexpression.Sibonisa ukuba oku akwenziwanga ngamaqela amakhulu e-LRRK2 okanye ukulandelwa kwe-ubiquitin kwii-aggregates.Okubalulekileyo, ukungaqhelekanga okunjalo akubonwa ngokugqithiswa kweprotheni enxulumene ne-LRRK1.Idatha yethu iphakamisa ukuba i-LRRK2 inqanda ukucocwa kwe-proteasome substrate s phezulu komsebenzi we-proteasome catalytic, ithanda ukuqokelelwa kweeprotheni kunye nokwakhiwa kwe-aggregate.Ngaloo ndlela, sinika ikhonkco ye-molecular phakathi kwe-LRRK2, eyona nto ixhaphakileyo eyaziwayo imbangela yePD, kunye ne-phenotype echazwe ngaphambili yokuqokelela iprotheni.
