I-Polystyrene sulfonic acid CAS: 28210-41-5
| Inombolo Yekhathalogu | XD90753 |
| Igama lemveliso | Polystyrene sulfonic acid |
| CAS | 28210-41-5 |
| Ifomula yeemolekyuli | C8H8O3S |
| Ubunzima beMolekyuli | 184.212 |
| Iinkcukacha zokuGcina | I-Ambient |
Ukucaciswa kweMveliso
| Imbonakalo | Ulwelo olunyulu |
| Isivavanyi | 99% |
I-Hyperkalemia ngexesha le-renin-angiotensin-aldosterone system inhibition (RAAS-I) inokuthintela i-dosing efanelekileyo.Iinketho zonyango ziquka i-sodium polystyrene sulfonate potassium binding resins, kodwa iinkxalabo zokhuseleko kunye nokusebenza kakuhle zikhona, kubandakanywa ne-colonic necrosis ehambelanayo (CN).Ezinye ii-agent ziye zafundiswa, kodwa iindleko-utility azizange ziqikelelwe. Senze uhlalutyo lweendleko-eziluncedo kwizigulane ezingalaliswanga ≥ iminyaka eyi-18 ubudala efumana i-RAAS-I engapheliyo, enembali ye-hyperkalemia okanye isifo esingapheliyo sezintso, echazwe nokuba yi-sodium polystyrene sulfonate. okanye ithiyori "yeyeza X" yokubopha intlaka ye-hyperkalemia engapheliyo.Idatha yafunyanwa kuncwadi olukhoyo.Sisebenzise imodeli yokuhlalutya isigqibo kunye nohlalutyo lwe-Monte Carlo olunokwenzeka, ukusuka kumbono womhlawuli wezempilo kunye nexesha le-12 lenyanga.Iindleko zilinganiswe ngeedola zaseMelika.Ukusebenza kulinganiswe kwiminyaka yobomi ehlengahlengisiweyo (i-QALYs), kunye nokunyuka kweendleko ezisebenzayo (ICERs) .I-Drug X ayinakuxabisa ngaphezu kwe-$ 10.77 ngedosi yemihla ngemihla ukuba ibe yindleko, ngokuvuma ukuhlawula ( WTP) umda we-$ 50,000 / QALY.Kwi- $ 40.00 ngedosi yemihla ngemihla, ichiza X lizuze umlinganiselo weendleko ezongeziweyo ezisebenzayo ze-$26,088,369.00 nge-QALY nganye efunyenweyo.Uhlalutyo lwendlela enye ye-sensitivity lubonise i-polystyrene sulfonate ye-sodium ibe yindleko esebenzayo kwi-CN izehlo ≤ 19.9%.Ukulinganiselwa kubandakanya ulwazi olungaphelelanga kwiziphumo zezigulane zangaphandle kunye nokungabikho kwedatha ngokuthelekisa ngokuthe ngqo i-sodium polystyrene sulfonate kwezinye iindlela ezinokuthi zingabikho.Ezinye iindlela zingenako ukuhlawula iindleko ngaphandle kokuba ixabiso elifanayo ne-sodium polystyrene sulfonate.Olu hlalutyo lunokukhokela izigqibo malunga nokwamkelwa kwezinye ii-agent zokulawula i-hyperkalemia engapheliyo, kwaye iphakamisa ukuba i-sodium polystyrene sulfonate iqeshwe njengolawulo olusebenzayo kwizilingo zeklinikhi zala mayeza.
