Iimveliso

I-R-PMPA, ekwaziwa ngokuba yi-tenofovir disoproxil fumarate (TDF), liyeza le-antiviral elisetyenziswa ikakhulu kunyango lwe-human immunodeficiency virus (HIV) kunye nosulelo olungapheliyo lwe-hepatitis B (HBV).Yimveliso yomlomo eguqulwayo ibe yimo esebenzayo, i-tenofovir diphosphate, ngaphakathi emzimbeni.R-PMPA iyinxalenye yamachiza abizwa ngokuba yi-nucleotide reverse transcriptase inhibitors (NRTIs).Isebenza ngokuthintela i-enzayim ye-reverse transcriptase, eyimfuneko kuphindaphindo lwe-HIV ne-HBV.Ngokuthintela eli nyathelo libalulekileyo kwinkqubo yophindaphindo lwentsholongwane egazini, i-R-PMPA inceda ukunciphisa umthamo wentsholongwane egazini kwaye icothise ukuqhubeka kwezifo. (CART) irejimeni.Inikwa kunye namanye amachiza ee-antiretroviral asuka kwiindidi ezahlukeneyo zamachiza ukomeleza ukusebenza ngempumelelo kunye nokunciphisa ukukhula kokunganyangeki ngamachiza.Irejimeni ethile ye-CART iya kuxhomekeka kwimiba yesigulane ngasinye, njengenqanaba losulelo lwe-HIV, imbali yonyango lwangaphambili, kunye naziphi na iimeko zempilo ezihambelanayo.Kunyango lwe-HBV engapheliyo, i-R-PMPA idla ngokumiselwa njenge-monotherapy okanye idibene amanye amayeza e-antiviral.Ubude bonyango bunokwahluka ngokuxhomekeke kubukhulu bosulelo kunye nempendulo yomntu kwiyeza.I-dosage ye-R-PMPA iya kugqitywa ngumsebenzi wezempilo ngokusekelwe kwizinto ezifana nokusebenza kwezintso, ubudala, ubunzima, kunye nobukho bayo nayiphi na into. ezinye iimeko zonyango.Kubalulekile ukulandela imiyalelo ye-dosing emiselweyo kwaye ungahlengahlengisi umthamo ngaphandle kokubonisana nomboneleli wezempilo.R-PMPA ngokuqhelekileyo ukunyamezela kakuhle, kodwa njengawo nawaphi na amayeza, kunokubangela imiphumo emibi.Iziphumo ebezingalindelekanga eziqhelekileyo ziquka isicaphucaphu, ukuhlanza, urhudo, kunye nentloko.Kwezinye iimeko, i-R-PMPA inokubangela iziphumo ezibi kakhulu, ezifana nokungasebenzi kakuhle kwezintso okanye ukulahleka kwethambo lamaminerali.Ukuhlolwa rhoqo komsebenzi wezintso kunye nempilo yethambo kuyacetyiswa ngexesha lonyango.Kubalulekile ukuthatha i-R-PMPA kanye njengoko kumiselweyo kwaye ubambelele kwirejimeni yonyango rhoqo.Ukuphoswa kweedosi okanye ukuyeka unyango phambi kwexesha kunokukhokelela kuphuhliso lokunganyangeki ngamachiza kunye nokuncipha kokusebenza konyango. Isishwankathelo, i-R-PMPA (tenofovir disoproxil fumarate) liyeza le-antiviral elisetyenziswa kunyango losulelo lwe-HIV kunye nosulelo olungapheliyo lwe-HBV.Isebenza ngokuthintela inkqubo yophindaphindo lwentsholongwane kwaye kaninzi isetyenziswa njengenxalenye yonyango oludityanisiweyo lwe-HIV.Ukubeka iliso ngokusondeleyo kunye nokubambelela kunyango kubalulekile kwiziphumo ezizezona zilungileyo.Ukubonisana nengcali yezempilo kubalulekile ukumisela isicwangciso sonyango esifanelekileyo kunye nokulawula naziphi na iziphumo ebezingalindelekanga.