Iimveliso

I-Sitagliptin liyeza elikudidi lwamachiza abizwa ngokuba yi-dipeptidyl peptidase-4 (DPP-4) inhibitors.Isetyenziswa ngokuyintloko ekulawuleni uhlobo lwe-2 yeswekile mellitus.Isifo seswekile senzeka xa umzimba ungakwazi ukulawula ngokufanelekileyo amanqanaba eswekile yegazi, okukhokelela kumanqanaba aphezulu eglucose egazini.I-Sitagliptin isebenza ngokuthintela i-DPP-4 enzyme, enoxanduva lokuphula i-incretin hormone.La mahomoni anyusa ukukhutshwa kwe-insulin kwaye anciphisa imveliso yeglucagon, ekugqibeleni ekhokelela kumazinga alawulwayo eswekile yegazi.Ngokuthintela i-enzyme ye-DPP-4, i-sitagliptin ivumela i-hormone ye-incretin ukuba ihlale isebenza ixesha elide, ngaloo ndlela iphucula ulawulo lweswekile yegazi.Idosi emiselweyo yingcali yezempilo iya kuxhomekeka kwizinto zesigulana ngasinye, njengobunzulu besifo seswekile kunye namanye amayeza asetyenziswayo.Kubalulekile ukulandela imiyalelo ye-dosing emiselweyo ngokucokisekileyo kwaye ungahlengahlengisi umthamo ngaphandle kokubonisana nomboneleli wezempilo.I-Sitagliptin isoloko isetyenziselwa ukuncedisa ukutya kunye nokuzivocavoca ekulawuleni uhlobo lwe-2 yesifo sikashukela.Ngokuqhelekileyo imiselwe kunye nokuguqulwa kwendlela yokuphila kunye namanye amayeza e-antidiabetic, njenge-metformin.Ngokudibanisa iindlela ezahlukeneyo zesenzo, ezifana ne-sitagliptin ye-DPP-4 inhibition kunye nokuphuculwa kwe-metformin ye-insulin sensitivity, ulawulo olungcono lwe-glycemic lunokuphunyezwa.Ukusebenza kwe-sitagliptin ekulawuleni amanqanaba eswekile yegazi kubonakaliswe kwiimvavanyo ezininzi zeklinikhi.Uphononongo lubonise ukuba lunokunciphisa kokubili ukutya kunye ne-postprandial (emva kokutya) amanqanaba eglucose, ukunciphisa amanqanaba e-glycated hemoglobin (HbA1c), kunye nokuphucula ulawulo lwe-glycemic jikelele. njengentloko ebuhlungu, usulelo lwephecana eliphezulu lokuphefumla, kunye nokuphazamiseka kwesisu esifana nesicaphucaphu okanye urhudo.Njengalo naliphi na iyeza, ukuchasana okunzulu kunye neziphumo ebezingalindelekanga ezinqabileyo kodwa ezinzima zinokwenzeka, ngoko ke kubalulekile ukuba uxele naziphi na iimpawu ezingaqhelekanga okanye eziqatha kwingcali yezempilo ngokukhawuleza. .Njenge-DPP-4 inhibitor, inceda ukuphucula ulawulo lwe-glycemic ngokwandisa umsebenzi we-incretin hormone.Xa isetyenziswe kunye nokuguqulwa kwendlela yokuphila kunye namanye amayeza e-antidiabetic, i-sitagliptin ingaba sisixhobo esisebenzayo ekulawuleni amanqanaba eswekile yegazi kunye nokulawula uhlobo lwe-2 yeswekile.Ukubeka iliso ngokusondeleyo kunye nokubonisana nomboneleli wezempilo kubalulekile kwiziphumo ezilungileyo.