I-Rapamycin esuka kwi-Streptomyces hygroscopicus CAS: 53123-88-9 Imhlophe ukuya kumhlophe-mhlophe okanye umgubo wekristale omthubi
| Inombolo Yekhathalogu | XD90356 |
| Igama lemveliso | I-Rapamycin evela kwi-Streptomyces hygroscopicus |
| CAS | 53123-88-9 |
| Ifomula yeemolekyuli | C51H79NO13 |
| Ubunzima beMolekyuli | 914.17 |
| Iinkcukacha zokuGcina | -20 °C |
| IKhowudi yoMrhumo eHarmonized | 2942000000 |
Ukucaciswa kweMveliso
| Isivavanyi | 99% |
| Imbonakalo | Imhlophe ukuya kumhlophe-omhlophe okanye umgubo wekristale omthubi |
I-Rapamycin, iyeza eliye labonakaliswa ukwandisa ixesha lokuphila kwiigundane, livimbela indlela ekujoliswe kuyo ye-rapamycin (TOR), indlela enkulu elawula ukukhula kweeseli kunye nesimo samandla.Kuye kwacingelwa ukuba i-rapamycin kunye ne-dietary restriction (DR) yandisa ixesha lokuphila ngeendlela ezifanayo/iindlela ezifanayo.Ukusebenzisa uhlalutyo lwe-microarray, sithelekisa i-transcriptome ye-white adipose tissue ukusuka kwiigundane ezondliwe i-rapamycin okanye i-DR-diet kwiinyanga ze-6.Uhlalutyo lwe-multidimensional scaling kunye ne-heatmap lubonise ukuba i-rapamycin ayinayo impembelelo kwi-transcriptome xa kuthelekiswa ne-DR.Ngokomzekelo, imibhalo emithandathu kuphela yatshintshwa kakhulu yi-rapamycin ngelixa iigundane zondliwe i-DR zibonise utshintsho oluphawulekayo kwimibhalo ye-1000.Ukusebenzisa uhlalutyo lwendlela yobuchule, sifumene ukuba i-biosynthesis ye-stearate kunye ne-circadian rhythm signaling yatshintshwa kakhulu yi-DR.Iziphumo zethu ezibonisa ukuba i-DR, kodwa kungekhona i-rapamycin, inefuthe kwi-transcriptome ye-adipose tissue, ebonisa ukuba ezi zimbini zokukhwabanisa zandisa ixesha lokuphila ngeendlela ezahlukeneyo / iindlela.
