I-Riboflavin Cas: 83-88-5 i-Orange powder 99%
| Inombolo Yekhathalogu | XD90448 |
| Igama lemveliso | Riboflavin |
| CAS | 83-88-5 |
| Ifomula yeemolekyuli | I-C17H20N4O6 |
| Ubunzima beMolekyuli | 376.36 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29362300 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo oworenji |
| Isivavanyi | >99% |
| Iintsimbi ezinzima | <0.001% |
| AS | <0.002% |
| Ilahleko ekomisweni | <0.5% |
| Intsalela kwi-Ignition | <0.2% |
| Ukujikeleza okuthe ngqo | -120 ukuya -140 |
IRiboflavin, ekwabizwa ngokuba yivithamin B2, ithuthwa kwinwebu yebhayoloji ukuya kumalungu ahlukeneyo ngeenkqubo zothutho.I-Riboflavin transporter RFVT3 ibonakaliswe emathunjini amancinci kwaye iye yacetyiswa ukuba ifakwe kwi-membrane ye-apical yeeseli ze-epithelial zamathumbu.Kolu phononongo, siphande ukubandakanyeka kokusebenza kwe-RFVT3 ekufunxeni i-riboflavin kusetyenziswa iiseli ze-epithelial T84 zamathumbu kunye nempuku yamathumbu amancinci.Iiseli ze-T84 zivakalise i-RFVT3 kwaye zigcinwe unidirectional riboflavin uthutho oluhambelana nokufunxwa kwamathumbu.Ukuthathwa kwe-Apical [(3)H] riboflavin bekuxhomekeke kwi-pH kwiiseli ze-T84.Oku kunyuswa akuzange kuchaphazeleke yi-Na (+) yokuncipha kwi-apical pH 6.0, nangona iyancipha kakhulu kwi-apical pH 7.4.I- [(3)H] i-riboflavin efunyenwe kwicala le-apical yeeseli ze-T84 yayithintelwe ngokubonakalayo yi-RFVT3 inhibitor ekhethiweyo ye-methylene blue kwaye yehla kakhulu ngokugqithiselwa kwe-RFVT3-i-RNA encinci-ephazamisayo.Kwindlela yesisu, i-RFVT3 ibonakaliswe kwi-jejunum kunye ne-ileum.Impuku yejejunal kunye neleal permeabilities ye [(3)H] riboflavin yalinganiswa ngendlela ye-in situ evaliweyo kwaye yancitshiswa kakhulu nge-methylene blue.Ezi ziphumo zibonisa ngamandla ukuba i-RFVT3 iya kubandakanyeka ngokusebenzayo ekufunxeni kwe-riboflavin kwiiseli ze-apical ze-epithelial zamathumbu.
