Iimveliso

I-Rosuvastatin Intermediates ZD9, eyaziwa nangokuthi yi-Z-4- (4-Fluorophenyl) -6-Isopropyl-2-[(N-Methyl-N-Methylsulfonyl) Amino]Pyrimidin-5-Yl, i-chemical compound esebenza njengento ebalulekileyo. ephakathi kwi-synthesis ye-cholesterol-ehlisa iyeza iRosuvastatin.Esi siphakathi sidlala indima ebalulekileyo ekuveliseni i-Rosuvastatin, eyeklasi yamachiza eyaziwa ngokuba yi-statins.ZD9 isebenza njenge-precursor compound kwi-multistep synthesis ye-Rosuvastatin.Ngexesha lenkqubo yokuvelisa, i-ZD9 ifumana ukuguqulwa kweekhemikhali ezahlukeneyo ekugqibeleni ivelise imveliso yokugqibela, i-Rosuvastatin.Olu qulunqo lubandakanya ukuhlonyelwa kwamaqela asebenzayo okongezelelweyo kwi-molecule ye-ZD9, okubangelwa ukuqulunqwa kwesithako seyeza esisebenzayo, i-Rosuvastatin.Rosuvastatin isetyenziswa ngokubanzi kunyango lwe-hypercholesterolemia, imeko ebonakaliswe ngamanqanaba aphezulu e-cholesterol egazini.Isebenza ngokuthintela i-enzyme HMG-CoA reductase, edlala indima ebalulekileyo kwi-cholesterol synthesis emzimbeni.Ngokunciphisa ukuveliswa kwe-cholesterol, i-Rosuvastatin inceda ukunciphisa amanqanaba e-cholesterol yonke, kubandakanywa ne-low-density lipoprotein (LDL) ye-cholesterol, edla ngokubizwa ngokuba yi-cholesterol "embi". kunye nendlela esebenzayo.Isebenza njengebhloko yesakhiwo esenza uchungechunge lwee-chemical reactions, ezikhokelela ekubunjweni kweebhondi ezithile kunye namaqela asebenzayo ayimfuneko kwi-Rosuvastatin's pharmacological activity.I-synthesis ye-Rosuvastatin yinkqubo eyinkimbinkimbi, kwaye i-intermediate nganye, kuquka i-ZD9, ibalulekile ekuqinisekiseni. ukubunjwa okufanelekileyo kwemveliso yokugqibela.Ngaphandle kwe-ZD9, i-synthesis ye-Rosuvastatin ayinakwenzeka, inqanda ukuveliswa kweyeza elibalulekileyo lokunciphisa i-cholesterol. Isishwankathelo, i-Rosuvastatin Intermediates ZD9 isebenza njengeyona nto ibalulekileyo kwi-synthesis yeyeza elisetyenzisiweyo lokunciphisa i-cholesterol, i-Rosuvastatin.Isebenza njengebhloko yokwakha eyenza utshintsho lweekhemikhali ukuze ekugqibeleni ivelise isithako esisebenzayo soxubo mayeza.Ngokudlala indima ebalulekileyo kwinkqubo yokuvelisa, i-ZD9 inegalelo ekufumanekeni kweyeza elibalulekileyo kunyango lwamanqanaba aphezulu e-cholesterol kwizigulane.