I-S-Butyrylthiocholine iodide Cas: 1866-16-6 98% Ikristale emhlophe eqinileyo
| Inombolo Yekhathalogu | XD90143 |
| Igama lemveliso | S-Butyrylthiocholine iodide |
| CAS | 1866-16-6 |
| Ifomula yeemolekyuli | C9H20INOS |
| Ubunzima beMolekyuli | 317.23 |
| Iinkcukacha zokuGcina | -15 ukuya -20 °C |
| IKhowudi yoMrhumo eHarmonized | 29309098 |
Ukucaciswa kweMveliso
| Imbonakalo | Ukuqina kwekristale emhlophe |
| uAsay | >98% |
| Indawo yokunyibilika | 173 - 178 Deg C |
| Ukunyibilika | Inyibilika emanzini ukunika isisombululo esicacileyo esingenambala |
| Non-Volatile Matter | <1% |
Iikhompawundi ze-Multitarget zisanda kulandelwa kunyango olusebenzayo lwezifo ezinzima.Apha, sichaza uyilo kunye nokuhlanganiswa kweklasi yenoveli ye-shogaol-huprine hybrids, ekujongwe ukuba ibethe iithagethi ezininzi eziphambili ezibandakanyeka kwisifo se-Alzheimer.Ii-hybrids ziye zavavanywa kwi-vitro ngenxa yomsebenzi wazo wokuthintela ngokuchasene ne-acetylcholinesterase yabantu kunye ne-butyrylcholinesterase kunye nomsebenzi we-antioxidant (ABTS +, i-DPPH kunye ne-Folin-Ciocalteu assays), kunye neeseli ze-Escherichia coli ezingaguqukiyo kwi-Aβ42 yazo kunye ne-tau anti-aggregating activity.Kwakhona, ukungena kwabo kwengqondo kuye kwavavanywa (i-PAMPA-BBB assay).Nangona i-hybrids ingekho njenge-AChE inhibitors enamandla okanye i-antioxidant agents njenge-huprine yomzali Y kunye ne- [4] -shogaol, ngokulandelanayo, zisabonisa i-anticholinesterase enamandla kakhulu kunye nemisebenzi ye-antioxidant kwaye inamandla kakhulu i-Aβ42 kunye ne-tau anti-aggregating agents kune- iikhompawundi zabazali.Lilonke, i-shogaol-huprine hybrids ivela njengobuchopho obunomdla obungena kwi-anti-Alzheimer ekhokelayo.
Izicatshulwa zepolarity ezahlukeneyo ezifunyenwe kwiindawo ezahlukeneyo zezityalo (ingcambu, igqabi, intyatyambo kunye neziqhamo) zeSeseli rigidum zaphononongwa ngovavanyo olwahlukileyo lwe-antioxidant: iDPPH kunye ne-ABTS umsebenzi wokutshabalalisa ngokugqibeleleyo, ngokunciphisa ngokupheleleyo indlela yamandla kunye nomxholo opheleleyo we-flavonoids kunye ne-polyphenols. .Iioli eziyimfuneko kuzo zonke iindawo zezityalo zibonise iimpawu ezibuthathaka ze-antioxidant.Uluhlu lwe-inhibitory concentration ye-extracts ezivavanyiweyo, ngokuchasene neebhaktheriya i-Escherichia coli, i-Pseudomonas aeruginosa, i-Staphylococcus aureus, i-Bacillus cereus, kunye ne-fungi Candida albicans kunye ne-Aspergillus niger yayingu-0.01-1.50 mg / mL kunye ne-microbicidal-3mL 0.00.Ekusebenzisaneni ne-cholinesterase, zonke iioyile eziyimfuneko zingqineke zisebenza njenge-inhibitors.Ipesenti ephezulu yokuthintela ngokuchasene ne-cholinesterase yabantu kunye nehashe iboniswe yingcambu yeoli ebalulekileyo (i-38.20% kunye ne-48.30%, ngokulandelanayo) phakathi kweoli, kunye ne-root hexane extract (40.56% kunye ne-50.65% ngokulandelanayo).I-oyile ebalulekileyo kunye namacandelo aguquguqukayo kuzo zonke iindawo zezityalo zichongiwe yi-GC, i-GC-MS kunye ne-headspace / i-GC-MS.Uhlalutyo lwamanani lokudityaniswa kweziphumo lubonise ukuba ingcambu yokwakheka kwe-oyile yahluke kakhulu kwii-oyile ezibalulekileyo zezinye iindawo zesityalo.Uthathela ingqalelo yonke imisebenzi efundiweyo, ingcambu ye-hexane extract ibonise ezona mpawu zibalaseleyo.Ngenkqubo yolwelo oluphezulu lwechromatography edityaniswe ne-spectrometry yobunzima obuphezulu, awona malungu angama-30 aninzi aye achongwa kwizicatshulwa ezahlukeneyo zepolarity.Ubukho beendawo ezichongiweyo zanxulunyaniswa nemisebenzi ethile yebhayoloji, ngaloo ndlela kuyilwa iikhompawundi ezinokuthi zibe noxanduva lomsebenzi ngamnye obonisiweyo.
