Iimveliso

Isilivere ye-trifluoromethanesulfonate, ekwabizwa ngokuba yi-AgOTf, sisixhobo esinamandla nesisebenzayo esisetyenziswa kuguqulo lweekhemikhali ezahlukeneyo.Yeyona klasi ye-metal triflates, eluncedo kakhulu kwi-organic synthesis ngenxa ye-acidity ye-Lewis kunye nokukwazi ukuvula i-substrates.Enye yezicelo eziphambili zesilivere ye-trifluoromethanesulfonate njenge-catalyst kwi-organic reactions.Iyakwazi ukuququzelela iinguqu ezahlukeneyo, kuquka i-carbon-carbon bond form reaction reactions, njengeFriedel-Crafts alkylation kunye ne-acylation reactions, kunye ne-carbon-nitrogen bond form reaction reactions, njenge-N-acylation ye-amines okanye i-synthesis of amides.Ubume be-Lewis acidic be-AgOTf buyenza ikwazi ukulungelelanisa kunye ne-electron-rich rich substrates, ekhokelela ekuvulweni kweebhondi zekhemikhali ezithile kunye nokuququzelela ukusabela okufunekayo.Umsebenzi wayo we-catalytic uxabiseke ngokukodwa ekudityanisweni kwamayeza, amachiza e-agrochemicals, kunye neekhemikhali ezilungileyo.I-AgOTf ikwaluncedo ekukhuthazeni ukulungiswa ngokutsha kunye nokusabela kwebhayisikile.Iyakwazi ukuvuselela iindlela ezahlukeneyo zokusabela ngokutsha, ezifana nokuhlelwa ngokutsha kwe-Beckmann, eguqula i-oximes ibe yi-amides okanye i-esters, okanye ukulungiswa kwakhona kweeallical alcohols ukwenza i-carbonyl compounds.Ukongeza, inokunceda ekuphenduleni kwebhayisikile, ivumela ukwakheka kweekhompawundi ze-cyclic kunye neenkqubo zeringi ezintsonkothileyo.I-Lewis acidic character ye-AgOTf idlala indima ebalulekileyo kwezi ntshukumo ngokuququzelela uhlenga-hlengiso lwebhondi eyimfuneko kunye namanyathelo okuhamba ngebhayisikile.Ngaphezu koko, isilivere ye-trifluoromethanesulfonate isetyenziswa ekuvulweni kweebhondi ze-carbon-hydrogen (CH).Iyakwazi ukwenza iibhondi ze-CH ezikufutshane namaqela asebenzayo, njengasekusebenzeni kweebhondi ze-CH ezivumbayo okanye ukusetyenziswa kweebhondi ze-allylic okanye ze-benzylic CH.Oku kusebenze kuvumela ukusebenza okulandelayo kwe-CH bond, ekhokelela ekubunjweni kwe-carbon-carbon-carbon okanye i-carbon-heteroatom bond.Le ndlela, eyaziwa ngokuba yi-CH activation, yintsimi ekhula ngokukhawuleza kwi-organic synthesis kwaye ibonelela ngendlela efanelekileyo yokufikelela kwi-scaffolds eyinkimbinkimbi ye-molecular.Kuyafaneleka ukuba uqaphele ukuba i-AgOTf ivakalelwa kumswakama kunye nomoya, kwaye ngoko kufuneka iphathwe phantsi kweemeko ezilawulwayo.Iqhele ukusetyenziswa ngokwemilinganiselo emincinci, njengexabiso le-catalytic, ngenxa yokuphinda isebenze kwakhona.Ukunyamekela kufuneka kuthatyathwe ukusebenza kwindawo enomoya ococekileyo kunye nokukhusela i-reagent kwi-exposure yomswakama.Ngokufutshane, isilivere i-trifluoromethanesulfonate (AgOTf) i-reagent exabisekileyo kunye ne-catalyst in organic synthesis.Ubume bayo be-Lewis acidic bubangela ukuba isebenze i-substrates, ikhuthaze ukulungiswa ngokutsha kunye nokuphendulwa kwebhayisikile, kwaye ivule iibhondi ze-CH, ezikhokelela ekwenziweni kweemolekyuli eziyinkimbinkimbi zezinto eziphilayo.Nangona kunjalo, amanyathelo okhuseleko kufuneka athathwe xa kusingathwa kwaye kugcinwe i-AgOTf ukuqinisekisa uzinzo kunye nokuthintela ukusabela okungafunekiyo.