I-Spectinomycin dihydrochloride pentahydrate CAS: 22189-32-8 Umgubo omhlophe wekristale
| Inombolo Yekhathalogu | XD90369 |
| Igama lemveliso | ISpectinomycin dihydrochloride pentahydrate |
| CAS | 22189-32-8 |
| Ifomula yeemolekyuli | C14H24N2O7·2HCl·5H2O |
| Ubunzima beMolekyuli | 495.30 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29419090 |
Ukucaciswa kweMveliso
| Isivavanyi | 99% |
| Imbonakalo | Umgubo wekristale omhlophe |
Ukuphanda i-molecular epidemiology ye-isolates ye-Neisseria gonorrhoeae esuka e-Saskatchewan, eKhanada, usebenzisa i-Neisseria gonorrhoeae i-multi-antigen sequence typing (NG-MAST), kunye nokuvavanya imibutho phakathi kwe-antimicrobial susceptibility (AMS) kunye neentlobo ezithile zoxinzelelo (STs) .320cal isolates gonologies , eziqokelelwe phakathi kwe-2003 kunye ne-2008, zachwethezwa yi-NG-MAST.Ii-ST zaye zahlanganiswa ukuba enye yazo i-alleles yayiqhelekileyo kwaye enye yahluke nge-≤1% ngokulandelelana kwe-DNA.I-AMS inqunywe yi-agar dilution (CLSI) kwii-antibiotics ezisixhenxe. I-N gonorrhoeae isolates yasombululwa kwi-82 ngabanye be-NG-MAST STs kunye namaqela angama-18 e-NG-MAST ST kunye namaqela angama-25, 3655, 921, 3654, 3657 kunye ne-3656 equka i-53.4% (i-13.4%). /320) kwiindawo ezizimeleyo.I-N gonorrhoeae isolates echaphazeleka kuzo zonke ii-antimicrobials ezivavanyiweyo zazibaluleke kakhulu (p <0.05) ezinxulumene ne-ST 25 (87%).Olunye unxulumano olubalulekileyo phakathi kwe-ST kunye ne-AMS lubandakanya: I-ST 3654 kwaye yodwa kunye ne-inhibitory concentrations ye-≥0.03 mg / L kwisizukulwana sesithathu se-ceph alosporins;I-ST 3711 (100%) kunye ne-TRNG;kunye ne-ST / iqela le-3654 (43%) kunye nokumelana ne-chromosomal kwi-penicillin kunye ne-tetracycline.Amaqela amaninzi e-NG-MAST STs / amaqela adibaniswa kakhulu kunye ne-isolate kunye nokumelana ne-chromosomal kwi-tetracycline.I-Isolates ukumelana ne-ciprofloxacin (n=5) kunye ne-azithromycin (n=2) ibonakala njenge-STs nganye.Imibutho ephawulekayo yabonwa phakathi kwe-STs nganye, isondo kunye nobudala besigulane, kunye nokuhanjiswa kwengingqi kunye nexesha.Iintlangano phakathi kwe-N gonorrhoeae AMS kunye ne-NG-MAST STs zichongiwe kwaye zinokuba luncedo ekuqikeleleni i-AMS kwingingqi.Ngenxa yokuba ii-ST kumazwe ahlukeneyo zahluka kakhulu, ukusetyenziswa kwe-NG-MAST kuqikelelo lwe-AMS kwihlabathi jikelele kufuna uphononongo oluqhubekayo.
