I-Doxycycline hyclate CAS: 24390-14-5 99% I-crystalline powder ephuzi
| Inombolo Yekhathalogu | XD90368 |
| Igama lemveliso | Doxycycline hyclate |
| CAS | 24390-14-5 |
| Ifomula yeemolekyuli | C22H24N2O8·HCl·0.5C2H6O · 0.5H2O |
| Ubunzima beMolekyuli | 512.94 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29413000 |
Ukucaciswa kweMveliso
| Ukungcola A | <2% |
| UkungcolaB | <2% |
| Ukujikeleza okuthe ngqo | -105 ukuya -120 |
| pH | 2-3 |
| Ukungcola C | <0.5% |
| UkungcolaD | <0.5% |
| Ilahleko ekomisweni | 1.4-2.8% |
| Isivavanyi | 99% |
| Intsalela kwi-Ignition | <0.4% |
| Ukufunxa | 300-335 |
| Nakuphi na okunye ukungcola okukodwa | <0.5% |
| Imbonakalo | Umgubo wekristale otyheli |
| Ukungcola F | <0.5% |
| UkungcolaE | <0.5% |
| Utywala be-Ethyl | 4.5 - 6% |
| Ukufunxa ukungcola | <0.07% |
Ukwenziwa kwe-Biofilm kwi-abutment yamazinyo kunokukhokelela kwi-peri-implant mucositis kunye ne-peri-implantitis elandelayo.Ezi meko zinyangwa ngonyango ngamayeza okubulala iintsholongwane afana ne-doxycycline (Doxy).Apha sisebenzise indlela ye-electrochemical ye-cathodic polarization yokwambathisa i-Doxy kumphezulu ongaphandle wezinto ezixutywe ngamazinyo.Umphezulu ogqunywe yi-Doxy ubonise ukukhutshwa kwe-saline ene-phosphate-buffered ngexesha le-24 yokuqala.Nangona kunjalo, isixa esibalulekileyo se-Doxy sahlala kumphezulu kangangeeveki ezi-2 ngakumbi kwisampulu ye-5 mA-3 h enexabiso eliphezulu le-Doxy, ecebisa zombini isiqalo kunye nexesha elide lokubakho kwe-bacteriostatic komphezulu ogqunyiweyo.Ikhemistri yomphezulu yahlalutywa nge-x-ray photoelectron spectroscopy kunye ne-ion mass spectrometry yesibini.I-Topography yoMphezulu yavavanywa nge-electron microscopy ephuma endle kunye ne-blue-light profilometry.Ixesha elide le-polarization ukusuka kwi-1 h ukuya kwi-5 h kunye noxinano oluphezulu lwangoku ukusuka kwi-1 ukuya kwi-15 mA cm (-2) kubangele inani eliphezulu le-Doxy kwi-surfa ce.Umphezulu wawugqunywe ngumaleko we-Doxy ngaphantsi kwe-100 nm ngaphandle kotshintsho olubalulekileyo kwi-topography yomphezulu.Ipropathi ye-antibacterial ye-Doxy-coated surface yahlaziywa yi-biofilm kunye nokuhlolwa kweplanktonic ukukhula usebenzisa i-Staphylococcus epidermidis.Iisampulu ezigqunywe ngeDoxy zanciphisa ukuqokelelwa kwe-biofilm kunye nokukhula kweplanktonic kwinkcubeko yomhluzi, kwaye kwanqanda ukukhula kwebhaktheriya kwiipleyiti ze-agar.Impembelelo ye-antibacterial yayinamandla kwiisampuli ze-5 mA-3 h ezifakwe kwixabiso eliphezulu le-Doxy xa kuthelekiswa ne-1 mA-1 h.Ngokufanelekileyo, umphezulu ogqunywe ngeDoxy unamandla okuthintela ukoloniyali lwebhaktiriya xa utyhilekile kumlomo womlomo.I-Doxy-coating inokuba yindlela esebenzayo yokulawula i-peri-implant mucositis kunye nokuthintela ukuqhubeka kwayo kwi-peri-implantitis.
