Tazobactam Cas: 89786-04-9
| Inombolo Yekhathalogu | XD92373 |
| Igama lemveliso | Tazobactam |
| CAS | 89786-04-9 |
| Ifomu yemolekyulila | I-C10H12N4O5S |
| Ubunzima beMolekyuli | 300.29 |
| Iinkcukacha zokuGcina | -15 ukuya -20 °C |
| IKhowudi yoMrhumo eHarmonized | 29419000 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe ukuya kumhlophe |
| uAsay | 99% imizuzu |
| Amanzi | <0.5% |
| Ukujikeleza okuthe ngqo | +127 ukuya +139 |
| Iintsimbi ezinzima | <20ppm |
| Intsalela kwi-Ignition | <0.1% |
| Ukungcola ngokupheleleyo | <1.0% |
I-Tazobactam yi-penicillanic acid sulfone efana nomyalelo we-sulbactam.Yi-β-lactamaseinhibitor enamandla kune-sulbactam kwaye inomsebenzi obanzi kancinane kune-clavulanic acid.Ine-antibacterialactivity ebuthathaka kakhulu.I-Tazobactam ifumaneka kwi-fixed-dose, injectable injectables kunye ne-piperacillin, i-penicillin ebanzi ebandakanya umlinganiselo we-8: 1 we-piperacillin sodium ukuya kwi-tazobactamsodium ngobunzima kwaye ithengiswe phantsi kwegama lezorhwebo elithi Zosyn.I-pharmacokinetics yamachiza amabini afana kakhulu.Bobabini banobomi obufutshane obufutshane (t1/2 ～1 iyure), baneprotheyini encinci, banamava amancinane kakhulu emetabolism, kwaye bakhutshelwa kwiifomu ezingasebenziyo kumchamo kwindawo ephezulu.
Izibonakaliso ezivunyiweyo ze-piperacillin-tazobactamcombination ziquka unyango lwe-appendicitis, i-postpartumendometritis, kunye nesifo sokuvuvukala kwe-pelvic esibangelwa yi-β-lactamase-evelisa i-E. coli kunye ne-Bacteroides spp., izifo ze-skin andskin structure ezibangelwa yi-β-lactamase-producingS.aureus, kunye nenyumoniya ebangelwa yi-β-lactamase-producingstrains ye-H. influenzae.
