I-Tetracycline hydrochloride CAS: 64-75-5 99% Umgubo wekristale ophuzi
| Inombolo Yekhathalogu | XD90366 |
| Igama lemveliso | Tetracycline hydrochloride |
| CAS | 64-75-5 |
| Ifomula yeemolekyuli | C22H24N2O8 · HCl |
| Ubunzima beMolekyuli | 480.90 |
| Iinkcukacha zokuGcina | -15 ukuya -20 °C |
| IKhowudi yoMrhumo eHarmonized | 29413000 |
Ukucaciswa kweMveliso
| Ukuqukumbela | Ihambelana neBP2013, EP7, USP38 |
| Iintsimbi ezinzima | <0.005% |
| Ukungacoceki Okukodwa | <0.1% |
| Ukuchongwa | IR, UV, HPLC, TLC |
| pH | 1.8-2.8 |
| Ilahleko ekomisweni | <2.0% |
| Isinyibilikisi esishiyekileyo | n-Butanol <3000ppm |
| Isivavanyi | BP2013/EP7 99% |
| Uthuthu lweSulfate | <0.5% |
| Ukujikeleza okuthe ngqo | -240 ukuya -255 ° |
| Amandla | USP 38: >900ug/mg |
| Ukungcola ngokupheleleyo | <5% |
| Imbonakalo | Umgubo wekristale otyheli |
| I-4-epianhydrotetracycline | <2% |
| Imida yeMicrobial | Iyahambelana |
| 4-Epiteracycline | <3% |
| I-Anhydrotetracyoline | <0.5% |
| I-Chlortetracycline Hydrochloride | <0.5% |
| Intsalela yokunyibilika | <100ppm |
Ukuphuhliswa kokuchasana kwe-antimicrobial kunikwe ukugqithisa kunye nokusetyenziswa kakubi kwee-antimicrobial agents.I-Staphylococci yinxalenye yezityalo eziqhelekileyo kodwa zikwayi-pathogens enokuthi ixhathise ngokuyimfuneko kwii-antibiotics ezininzi ezaziwayo.Ukuxhathisa kwi-coagulase negative staphylococci (CoNS) kucetyiswa ukuba kuvele ngenxa yoxinzelelo olukhethileyo olulandela unyango lwe-antibiotic.Olu phononongo luphande ubukho bezona arhente zisithoba zisetyenziswa ngokuqhelekileyo kumchamo womntu kwizigulana ezingalaliswanga kwizibhedlele ezibini zaseGhana ngokunxulumene nokuxhathisa kwe-ConS.Umchamo kunye ne-ConS zathathwa isampuli (n = 246 kunye n = 96 ngokulandelanayo) kwizigulane kwizibhedlele ezimbini zaseGhana.I-CoNS ichongiwe kusetyenziswa i-Gram staining, i-coagulase test, kunye ne-MALDI-TOF / MS, kunye ne-antimicrobial susceptibility kwi-12 esetyenziswa ngokuqhelekileyo i-antimicrobials inqunywe yi-disk diffusion.Ngaphezu koko indlela yohlalutyo yaphuhliswa ukumisela ezona arhente zilithoba zixhaphakileyo zisetyenziswa kwi-antimicrobial eGhana ngokusebenzisa i-solid-ph ase extraction ngokudityaniswa ne-HPLC-MS/MS kusetyenziswa i-electron spray ionization.I-frequency ephezulu yokuchasana ne-ConS yabonwa kwi-penicillin V (98%), i-trimethoprim (67%), kunye ne-tetracycline (63%).I-S. haemolyticus yayiyeyona iqhelekileyo i-isolate (75%), ilandelwa yi-S. epidermidis (13%) kunye ne-S. hominis (6%).I-S. haemolyticus ikwayeyona ntlobo ibonakalisa ukomelela okuphezulu kokuxhathisa (82%).I-69% ye-CoNS eyodwa yayinganyangekiyo ngamachiza (≧ 4 antibiotics) kunye ne-45% ye-CoNS yayixhathisa i-methicillin.Ii-antimicrobial agents zichongiwe kwi-64% yeesampulu zomchamo ezihlalutyiweyo (n = 121) apho amachiza alwa ne-antimicrobial afunyenwe rhoqo yayiyi-ciprofloxacin (30%), i-trimethoprim (27%), kunye ne-metronidazole (17%).Iziphumo eziphambili zolu phononongo kukuba ukuxhaphaka kwe-antimicrobial efunyenwe kumchamo kwakusoloko kuninzi kunokuba kusetyenziswe ingxelo yezigulane kunye nokuxhaphaka kwe-S.
