I-Doxorubicin hydrochloride CAS: 25316-40-9 99% I-Orange-red Crystalline powder
| Inombolo Yekhathalogu | XD90367 |
| Igama lemveliso | Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| Ifomula yeemolekyuli | C27H29NO11·HCl |
| Ubunzima beMolekyuli | 579.98 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29419000 |
Ukucaciswa kweMveliso
| AmanziUmxholo | ≤ 4.0% |
| pH | 4.0-5.5 |
| Ukunyibilika | Inyibilika: emanzini, imethanol kunye ne-isotonic NaCl(aq).Ukunyibilika kakubi kwi-chloroform kunye nezinye izinyibilikisi eziphilayo. |
| Izinto ezinxulumeneyo | I-Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Isivavanyi | 99% |
| Izinyibilikisi ezishiyekileyo | I-acetone kunye notywala: ≤2.5% / i-acetone: ≤0.5% / iMethanol: ≤500ppm |
| Nakuphi na Okunye Ukungcola | ≤ 0.5% |
| Ukungcola ngokupheleleyo | ≤ 2.0% |
| Ubukhazikhazi | Ihambelana ne-USP |
| Imbonakalo | Orenji-bomvu Crystalline powder |
| Ukuchongwa | HPLC |
Izigulane ezine-P-glycoprotein kunye ne-HER2/neu (HER2) i-receptor-overexpressing yomhlaza webele idla ngokuba neziphumo ezibi zeklinikhi.Nangona kunjalo, akukho migca yeseli yomhlaza webele efumanekayo ekurhwebeni eyi-HER2/P-glycoprotein ene-double-positive, ethintela uphando kulo mmandla.Sinika ingxelo ngophuhliso kunye nophawu lomgca ongemva kweziyobisi kwi-HER2-positive breast. umgca weseli yomhlaza ngokudluliselwa okuzinzile kwe-ATP-binding cassette (ABC) ilungu le-subfamily B ilungu le-1 (ABCB1) i-gene enekhowudi ye-P-glycoprotein.ABCB1 amanqanaba e-gene expression ayephezulu emva kokudluliselwa, okukhokelela ekunyuseni kwe-40 kwi-P-glycoprotein intetho.Okubangel 'umdla kukuba, ukudluliselwa kwe-ABCB1 kwakhokelela ekunyukeni okuncinci kwi-HER2 gene kunye namanqanaba okubonakalisa iprotheni.Ukutshintshwa kwe-ABCB1 kwandisa amanqanaba okubonakaliswa kwe-P-glycoprotein kakhulu.Indlela esetyenziswe apha ekuphuhliseni lo mgca weseli ifanelekile ngokukhawuleza, i-stable induction ye-P-glycoprotein-mediated drug resistance xa kuthelekiswa neendlela ze-tr aditional.Uvavanyo lwe-in vitro cytotoxicity lubonisa ukuba lo mgca weseli unokumelana noluhlu olubanzi lwee-agent ze-chemotherapeutic.
