I-Tiamulin 98% Cas: 125-65-5
| Inombolo Yekhathalogu | XD91893 |
| Igama lemveliso | I-Tiamulin 98% |
| CAS | 125-65-5 |
| Ifomu yemolekyulila | C22H34O5 |
| Ubunzima beMolekyuli | 378.5 |
| Iinkcukacha zokuGcina | -20°C |
| IKhowudi yoMrhumo eHarmonized | 2918199090 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe |
| uAsay | 99% imizuzu |
| Indawo yokunyibilika | 170-1710C |
| alpha | D24 +20 ° (c = 3 kwi-abs ethanol) |
| Indawo yokubilisa | 482.8±45.0 °C(Kuqikelelwe) |
| ukuxinana | 1.15±0.1 g/cm3(Kuxelwe kwangaphambili) |
| ukunyibilika | I-DMSO:>10mg/mL (ishushu) |
| pka | 12.91±0.10(Kuqikelelwe) |
| umsebenzi wamehlo | [α]/D +30 ukuya +40° (c=1; CH2Cl2) |
I-Pleuromutilin yi-diterpene eveliswa zintlobo ezininzi ze-basidomycete, ngokukodwa i-genus Pleurotus, eyafunyanwa ngo-1951. yesenzo.I-Pleuromutilin inqanda ukuhlanganiswa kweprotheyini ngokuzibophelela kwi-domain V ye-23S rRNA kwaye oku kuye kwakhokelela ekuphuhlisweni kwee-analogue ezininzi ze-semi-synthetic njenge-antibiotics yesizukulwana esitsha, njenge-tiamulin kunye ne-retapamulin.
I-Pleuromutilins efana ne-tiamulin kunye ne-valnemulin sele isetyenziswe ixesha elithile kunyango lwezilwanyana ukunyanga izifo zehagu.Kutsha nje i-semisynthetic pleuromutilin, i-retapamulin, iye yaziswa njengonyango lwangaphakathi losulelo lwe-Gram-positive ebantwini.I-Pleuromutilins inqanda umsebenzi wokudluliselwa kwe-peptidyl webhaktiriya 50S ribosomal subunit ngokuzibophelela kwisiza esingu-A.
