Iimveliso

I-Trimethoprim i-lipophilic kunye ne-alkaline ebuthathaka yeklasi ye-bacteriostatic agent.Ngumgubo omhlophe okanye ophantse wamhlophe wekristale, awunavumba, ukrakra, kwaye unyibilika kancinane kwichloroform, ethanol okanye nakwiacetone, kodwa phantse awunyibiliki emanzini kwaye unyibilika kakhulu kwisisombululo se-acetic acid.Ine-antibacterial spectrum efana namachiza e-sulfa, kodwa enefuthe elinamandla lokulwa ne-antibacterial.Inempembelelo entle ekunyangeni i-Escherichia coli, i-Proteus mirabilis, i-Klebsiella pneumoniae, i-Staphylococcus saprophyticus, kunye neentlobo zezinye iibhaktheriya zegram-positive kunye ne-negative.Kodwa ayisebenzi ngokuchasene nosulelo lwePseudomonas aeruginosa.Ubuncinci boxinzelelo lwe-inhibitory luhlala lungaphantsi kwe-10 mg / L kunye nokusebenzisa yedwa kulula ukubangela ukuxhathisa ibhaktheriya, kwaye ngoko ke ayisetyenziswanga yodwa, kwaye ngokukodwa idityaniswe neyeza le-sulfa ukwenza ukulungiswa kweklinikhi yonyango lwe-urinary tract infections, intestinal. usulelo, usulelo lokuphefumla, isifo segazi, i-enteritis, i-typhoid fever, i-meningitis, i-otitis media, i-meningitis, i-sepsis kunye nosulelo lwezicubu ezithambileyo.Unempembelelo ekunyangeni i-typhoid kunye ne-paratyphoid effect engekho ngaphantsi kwe-ampicillin;Isenokudityaniswa namachiza e-sulfa asebenza ixesha elide kuthintelo kunye nonyango lwemalariya ye-falciparum enganyangekiyo ngamachiza.

Umgaqo osisiseko we-anti-bacterial ye-trimethoprim kukuphazamisa i-folate metabolism kwiibhaktheriya.Indlela ephambili yesenzo kukuvinjelwa okukhethiweyo komsebenzi we-dihydrofolate reductase kwiibhaktheriya ukuze i-dihydrofolate ingancitshiswa ibe yi-tetrahydrofolate.Ekubeni i-synthesis ye-folic acid iyona nxalenye ephambili ye-nucleic acid biosynthesis, kwaye ngoko ke imveliso ikhusela i-nucleic acids yebhakteria kunye neeprotheni synthesis.Ngaphezu koko, i-affinity ebophelelayo ye-trimethoprim (TMP) kwi-bacterial dihydrofolate reductase enzyme yomelele ngokuphindwe kahlanu kunaleyo kwi-mammalian dihydrofolate reductase.Indibaniselwano phakathi kwayo kunye namachiza e-sulfa inokubangela ukuvaleka kabini kwi-folic acid biosynthesis metabolism yebhaktheriya ukuze kubekho impembelelo ye-synergistic eya kuphucula umsebenzi we-antibacterial wamachiza e-sulfa, kwaye inokuguqula umphumo we-antibacterial kwisiphumo se-bactericidal esinciphisa ukunyangwa kweyeza. ubunzima.Ukongezelela, imveliso inokuphucula imiphumo ye-antibacterial yezinye iintlobo ze-antibiotics (ezifana ne-tetracycline, i-gentamicin).