Iimveliso

I-Vancomycin hydrochloride yi-glycopeptide antibiotics kwaye yityuwa ye-hydrochloride ye-vancomycin.Imhlophe okanye imhlophe njengomgubo wekristale kwiqondo lobushushu begumbi.Indlela yokusebenza kwayo kukuba inokubophelela ngokunxulumana okuphezulu kwi-poly-terminus alanyl-alanine ye-precursor peptide ebekwe eludongeni lweseli iiseli zebhaktheriya ezibuthathaka, ivalela i-biosynthesis ye-peptide glycan polymer ebumba udonga lweseli yebhaktiriya, kwaye ke ngoko. okukhokelela kwiziphene zodonga lweseli kunye nokubulala ngakumbi iibhaktheriya.Ukongeza, kunokwenzeka ukuba utshintshe ukunyanzeliswa kwe-membrane yeseli yebhakteria, kwaye ukhethe ngokunqanda ukuhlanganiswa kwe-RNA.Uphawu lwe-vancomycin hydrochloride yimpembelelo eyomeleleyo ye-bactericidal ngokuchasene neebhaktheriya ze-Gram-positive ezifana ne-Staphylococcus aureus, i-Staphylococcus epidermidis, i-Streptococcus pyogenes, kunye ne-streptococcus pneumoniae.Ikwanazo neziphumo ezithile ezichasene neebhaktheriya kwiStreptococci anaerobius, Clostridium difficile, Bacillus anthracis, Actinomycetes, Corynebacterium diphtheria, Neisseria gonorrhoeae, Streptococcus viridans, Streptococcus bovis, kunye neStreptococcus faecalis.Nangona kunjalo, kwiibhaktheriya ezininzi ze-Gram-negative, i-Mycobacterium, i-Rickettsia genus, i-Chlamydia okanye i-fungi, ayisebenzi.Isetyenziswa ngokweklinikhi kunyango losulelo olubangelwa yi-methicillin-resistant Staphylococcus aureus kunye nezinye iibhaktheriya: i-sepsis, i-endocarditis, i-osteomyelitis, isifo samathambo, ukwenzakala okutshisayo, ukwenzakala kotyando kunye nolunye usulelo oluphezulu lwesibini, inyumoniya, ithumba lemiphunga, i-empyema, i-peritonitis, i-meningitis, ipseudomembranous colitis, kunye nosulelo lwesikhumba kunye nezicubu ezithambileyo.Lolona khetho luphambili kwizigulane ezingadibaniyo nepenicillin kwaye ziphethwe yi-enterococcal endocarditis kunye neCorynebacterium (class diphtheria sp) endocarditis.