Iimveliso

I-Acetoxy Empagliflozin, ekwaziwa njenge-empagliflozin acetate, luhlobo olulungisiweyo lwechiza le-antidiabetic empagliflozin.I-Empagliflozin yeyodidi lweziyobisi ezaziwa ngokuba yi-sodium-glucose co-transporter 2 (SGLT2) inhibitors, ezisetyenziselwa ikakhulu ukulawula uhlobo lwe-2 yesifo sikashukela.Ngokunqanda le proteni, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-enye yikhemikhali entsonkothileyo ene- igama lekhemikhali elide.Iwa phantsi kodidi lwe-triMethylsilyloxy pyranones, ezisetyenziswa ngokubanzi kwizicelo ezahlukeneyo zenzululwazi nezoshishino.Olunye lolona setyenziso lubalulekileyo lwe (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-( (i-triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-enye njengeqela elikhuselayo kwi-organic synthesis.Amaqela akhuselayo ngamaqela asebenzayo okwethutyana asetyenziselwa ukukhusela iindawo ezithile ezisebenzayo kwimolekyuli ngexesha lokusabela kweekhemikhali.Kwimeko ye (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-enye, amaqela e-triMethylsilyloxy asebenza njengeenxalenye ezikhuselayo. .Ngexesha lokusabela, la maqela akhusela amaqela athile asebenzayo ekufumaneni iimpendulo ezingafunekiyo, evumela ukusabela okufunwayo ukuba kuqhubeke kakuhle.Emva kokuba i-reaction igqityiwe, amaqela e-triMethylsilyloxy anokususwa ngokulula, abonise amaqela asebenzayo okuqala.Olunye usetyenziso lwe (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy) I-Methyl)tetrahydro-2H-pyran-2-enye ikwi-synthesis ye-organic compounds.Ingasetyenziswa njengebhloko yokwakha ukwakha izakhiwo ezintsonkothileyo.Iimpawu zayo ezikhethekileyo zeekhemikhali kunye nokusebenza kwakhona kwenza kube sisixhobo esibalulekileyo ekuphuhliseni amaqumrhu emichiza emitsha.Iikhemisti zingasebenzisa (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-enye ukwazisa amaqela athile asebenzayo okanye ukwenza imolekyuli ethile. i-scaffolds ukufunda imisebenzi yebhayoloji yeekhompawundi okanye ukuphuhlisa amachiza amatsha.Ukongeza, le khompawundi inokufumana izicelo kwinkalo yenzululwazi yezinto.Ubukho bayo njengeqela elisebenzayo kwi-molecule inokunika iimpawu ezithile ezinqwenelekayo kwizinto eziphathekayo.Ngokomzekelo, inokwandisa ukunyibilika kwi-solvents ethile okanye ukuphucula iimpawu zokwenza ifilimu, iyenze ibe luncedo kwiingubo okanye i-adhesives.(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-(( i-triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-enye yikhompawundi ekhethekileyo enokusetyenziswa ngeendlela ezahlukeneyo kumacandelo ahlukeneyo enzululwazi nezoshishino.Ikhono layo lokusebenza njengeqela elikhuselayo kwaye lisebenze njengebhloko yokwakha kwi-chemistry yokwenziwa, kunye nokusetyenziswa kwayo okunokwenzeka kwisayensi yezinto eziphathekayo, yenza ukuba ibe yinto ebalulekileyo ekuphuhliseni iimolekyuli ezintsha kunye nezixhobo.Nangona kunjalo, usetyenziso oluchanekileyo kunye nokusetyenziswa kwayo kunokwahluka, ngokuxhomekeke kwiimfuno ezithile kunye neenjongo zeprojekthi ethile yesayensi okanye yezoshishino.