Iigundane zilawulwa idosi enye yemvelaphi yesityalo i-phenolic antioxidant Quercetin (QC) kwi-free, i-liposome efakwe kwi-liposome kunye ne-galactosylated liposome efakwe kwiifom ze-2 h ngaphambi kwe-hepatotoxic dose ye-carbontetrachloride (CCl4, 40% v / v kwioli yeoli, 1 ml / kg b .wt).Phakathi kwezo ntlobo zintathu ezahlukeneyo ze-QC ezivavanyiweyo, kuphela i-galactosylated liposomal QC inikeze ukhuseleko olubalulekileyo kwi-CCl4 eyenza umonakalo we-hepatic oxidative.Emva kwe-24 h ye-injection (SC) iiseli ze-hepatic zeegundane zifunyenwe zichaphazeleka kwi-CCl4 eyenza umonakalo we-oxidative kwaye ibekwe iliso ngokunyuka kwexabiso le-conjugated diene kwi-membrane ye-hepatic.Ukunyuka okuphindwe kabini kwi-conjugated diene ngokungeniswa kwe-CCl4 kwancitshiswa ukuya kwinqanaba eliqhelekileyo nge-galactosylated liposomal QC yonyango lwangaphambili.I-Carbontetrachloride yenza umonakalo kwi-membrane kwiiseli ze-hepatic kwaye yagwetywa yi-serum yegazi ye-pathological kunye ne-hepathological tissue ukuhlolwa kwe-histopathological.Umonakalo we-membrane ngokungeniswa kwe-CCl4 uphinde wavavanywa kwinqanaba elincitshisiweyo le-membrane ye-plasma (PM) ebophe i-enzyme ye-Na +/K + ye-ATPase kwaye yanda kuphela ngokunyangwa kwangaphambili kwe-galactosylated liposomal QC.I-Carbontetrachloride ibangele ukwehla okukhulu kumanqanaba e-enzymatic kunye ne-molecular endogenous antioxidant kwiiseli ze-hepatic. Ukudakumba kwinkqubo ye-antioxidant kwiiseli ze-hepatic kuthintelwe ngokupheleleyo ngedosi enye ye-galactosylated lipsosomal QC ngaphambi konyango lwe-CCl4.Ukunyuka kwesibindi se-QC kuqikelelwa emva kwe-2 h ye-flavonoid injection (8.9 micromol / kg ubunzima bomzimba) (iifom zamahhala okanye ze-liposomal) kunye ne-85% ye-QC ejojowe ifunyenwe kwisibindi kwimeko ye-galactosylated liposomal QC.Ngelixa kuphela i-25% yedosi etotiweyo yafunyanwa esibindi xa isixa esifanayo se-QC yamahhala yatofwa.I-Carbontetrachloride iye yabangela utshintsho kwi-membrane fluidity kwaye yavavanywa ngokuhla kwe-membrane micro-viscosity.Unyango lwangaphambili lwe-QC lwamahhala lubangele ukuba kungabikho ukukhuselwa kwi-CCl4 eyonyuswa ukunyuka kwe-hepatic membrane fluidity, kanti i-galactosylated liposomal QC yenza ukhuseleko olubalulekileyo ekunyuseni.Iziphumo zolu phononongo zibonise ukuba i-QC kwi-liposome ye-galactosylated inokukhusela kakhulu kwi-CCl4 eyenza ukulimala kwe-hepatocellular.
