I-5-Methyluridine CAS: 1463-10-1 99% Umgubo omhlophe
| Inombolo Yekhathalogu | XD90567 |
| Igama lemveliso | 5-Methyluridine |
| CAS | 1463-10-1 |
| Ifomula yeemolekyuli | I-C10H14N2O6 |
| Ubunzima beMolekyuli | 258.228 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 2934999090 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe |
| Isivavanyi | 99% |
I-tRNA lolona didi lulungiswe kakhulu lweentlobo ze-RNA, kwaye uhlengahlengiso lufumaneka kwii-tRNAs kuzo zonke izinto eziphilayo ezivavanyiweyo.Ngaphandle kolwakhiwo lwazo lweekhemikhali ezahlukeneyo kakhulu kunye nobukho bazo kwii-tRNA ezahlukeneyo, ezenzeka kwiindawo ezahlukeneyo kwi-tRNA, iindlela ze-biosynthetic uninzi lohlengahlengiso lwe-tRNA lubandakanya i(s) inyathelo le-methylation.Ukufunyaniswa kwamva nje kubonakalise ukuntsonkotha okungazange kubonwe ngaphambili kwiipatheni zohlengahlengiso ze-tRNA, ulawulo kunye nomsebenzi wazo, zicebisa ukuba i-nucleoside nganye elungisiweyo kwi-tRNA inokuba nomsebenzi wayo othile.Nangona kunjalo, kwizityalo, ulwazi lwethu ngendima yohlengahlengiso lwe-tRNA yomntu kunye nendlela ezilawulwa ngayo lulinganiselwe kakhulu.Kwisikrini sofuzo esenzelwe ukuchonga izinto ezilawula ukuxhathisa kwesifo kunye nokusebenza kokukhusela kwi-Arabidopsis, sichonge i-SUPPRESSOR OF CSB3 9 (SCS9).Iziphumo zethu zityhila i-SCS9 ifaka i-tRNA methyltransferase elamla i-2'-O-ribose methylation yeentlobo ezikhethiweyo ze-tRNA kwi-antico don loop.Olu tshintsho lwe-SCS9-mediated tRNA luphucula ngexesha losulelo lwentsholongwane ye-Pseudomonas syringae DC3000, kunye nokungabikho kohlengahlengiso lwe-tRNA, njengoko kubonwe kwi-scs9 mutants, kubeka esichengeni ukhuseleko lwezityalo ngokuchasene nentsholongwane enye ngaphandle kokuchaphazela umqondiso we-salicylic acid (SA) indlela elawula iimpendulo zokuzikhusela kwizityalo.Iziphumo zethu zixhasa imodeli enika ukubaluleka kulawulo lohlengahlengiso oluthile lwe-tRNA yokunyusela impendulo esebenzayo yamajoni omzimba kwi-Arabidopsis, kwaye ke ngoko yandisa irepertoire yamacandelo eemolekyuli ayimfuneko kwimpendulo esebenzayo yokuxhathisa isifo.
