Iimveliso

I-C6 dicarboxylic acid, i-adipic acid, iyikhemikhali ebalulekileyo yeqonga kwishishini.Imveliso ye-Biobased ye-adipic acid yenye indlela ethembisayo kwindlela yangoku yepetrochemical.Apha, sixela i-biosynthesis ye-adipic acid isebenzisa indlela eyenziweyo ephefumlelwe ukuguqulwa kwe-beta-oxidation ye-dicarboxylic acids.Umzila we-biosynthetic uquka ukudibanisa kwe-acetyl-CoA kunye ne-succinyl-CoA ukwenza i-backbone ye-C6 kunye nokunciphisa okulandelayo, ukuchithwa kwamanzi, i-hydrogenation, kunye nokukhululwa kwe-adipic acid kwi-thioester yayo.Indlela yaqala yavavanywa kwi-vitro kunye ne-enzayimi yendlela ehlaziyiweyo kwaye emva koko yaziswa ngokusebenzayo kwi-Escherichia coli ye-biosynthesis kunye nokukhutshelwa kwe-adipic acid kwindawo yenkcubeko.Isihloko semveliso sandiswe malunga ne-20-fold ngokudityaniswa kokugaya ii-enzymes ezazifaneleke ngakumbi ukuvuselela ii-synthetic reactions kunye nokwanda kokufumaneka kwe-condensation substrates.Lo msebenzi ubonisa i-biosynthesis ethe ngqo ye-adipic acid ngendlela engeyiyo eyendalo yokwenziwa, enokuthi inike ukuveliswa kwayo kwakhona.