Uridine-5'-diphosphoglucuronic acid trisodium ityuwa CAS: 63700-19-6 Umgubo omhlophe
| Inombolo Yekhathalogu | XD90382 |
| Igama lemveliso | Uridine-5'-diphosphoglucuronic acid trisodium ityuwa |
| CAS | 63700-19-6 |
| Ifomula yeemolekyuli | I-C15H19N2O18P2Na3 |
| Ubunzima beMolekyuli | 646.20 |
| Iinkcukacha zokuGcina | < -4 °C |
Ukucaciswa kweMveliso
| Isivavanyi | 99% |
| Imbonakalo | Umgubo omhlophe |
Uphononongo lwangoku lujolise ekuphandeni impembelelo yetyhefu ye-irinotecan nge-biotransformation ye-glucoaurantio-obtusin kwi-aurantio-obtusin.Ulawulo lwe-Intraperitoneal (ip) ye-100 mg / kg i-aurantio-obtusin yandisa kakhulu i-toxicity ye-irinotecan, kodwa ukulawulwa kwe-ip ye-100 mg / kg i-glucoaurantio-obtusin ibonise impembelelo engafanelekanga kwi-irinotecan's toxicity.Ngaphaya koko, umatshini wachazwa ngokumisela amandla okuthintela i-glucoaurantio-obtusin kunye ne-aurantio-obtusin ngokubhekiselele kwi-glucuronidation metabolism ye-SN-38 ethathwe njengeyona mveliso isebenzayo enoxanduva lobutyhefu be-irinotecan.Iziphumo zibonise ukuba i-aurantio-obtusin ibonise inhibition enamandla yokhuphiswano ngokubhekiselele kwi-glucuronidation ye-SN-38, kodwa inhibition enokubakho engabalulekanga ye-glucoaurantio-obtusin ukuya kwi-SN-38 glucuronidation yabonwa.Ezi ziphumo zibonise ukuba i-biotransformation ye-glucoaurantio-obtusin ukuya kwi-aurantio-obtusin yonyuse ubutyhefu be-irinotecan ngokunyuka kokuthintelwa kwe-SN-38 glucuronidation.
