Albendazole Cas: 54965-21-8
| Inombolo Yekhathalogu | XD91873 |
| Igama lemveliso | Albendazole |
| CAS | 54965-21-8 |
| Ifomu yemolekyulila | I-C12H15N3O2S |
| Ubunzima beMolekyuli | 265.33 |
| Iinkcukacha zokuGcina | 2-8°C |
| IKhowudi yoMrhumo eHarmonized | 29332990 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe wekristale |
| uAsay | 99% imizuzu |
| Indawo yokunyibilika | 208-210 °C |
| ukuxinana | 1.2561 (uqikelelo olurhabaxa) |
| isalathiso se-refractive | 1.6740 (uqikelelo) |
| ukunyibilika | Ayinyibiliki ngokoqobo emanzini, inyibilika ngokukhululekileyo kwi-anhydrous formic acid, inyibilika kancinane kwi-methylene chloride, ayinyibiliki kwi-ethanol (96 pesenti). |
| pka | 10.72±0.10(Kuqikelelwe) |
| Ukunyibilika kwamanzi | 0.75mg/L(209 ºC) |
IAlbendazole lichiza elisetyenziselwa ukunyanga izifo ezibangelwa zizifunxi-gazi.Inokunikwa ukunyanga usulelo olunqabileyo lobuchopho (neurocysticercosis) okanye inokunikwa ukunyanga usulelo lwe-parasitic olubangela urhudo olubalulekileyo (microsporidiosis).
I-derivative ye-benzimidazole, i-albendazole liyeza elinomthamo obanzi we-antihelmintic.Ibonisa impembelelo ye-antihelmintic ngokumelene ne-cestodes enobucayi kunye nematodes ngokuthintela inkqubo yokunyuka kwe-glucose ngama-parasites, ebonakaliswe ekunciphiseni i-glycogen reserves kunye nokunciphisa okulandelayo kwinqanaba le-adenosintriphophate.Ngenxa yoko, isifunxi-gazi siyayeka ukuhamba size sife.Isetyenziselwa ukusuleleka kwi-Acaris lumbricoides, i-Ancylostoma duodenale, i-Necator americanus, i-Enterobius vermicularis, kunye ne-Trichuris trichiura.Izithethantonye zeli chiza zi-SKF 62979 kunye nezinye.
I-Methyl 5-(propylthio)-2-benzimidazolecarbamate (Eskazole,Zentel) sisigubu esibanzi se-anthelmintic esingathengiswanga ngoku eMntla Melika.Ifumaneka kumenzi wesiseko sokusetyenziswa ngovelwano.I-Albendazole isetyenziswa kakhulu kwihlabathi lonke ukunyanga usulelo lwe-intestinalnematode.Isebenza njengedosi enye yonyango lwe-ascariasis, usulelo lweHookworm lweHlabathi eLitsha neliDala, kunye ne-trichuriasis.Unyango lwedosi eninzi kunye ne-albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, kunye nesifo se-hydatid.Ukusebenza kwe-albendazole ngokuchasene ne-tapeworms (cestodes) ngokuqhelekileyo kuyaguquguquka kwaye akubonakalisi.
I-Albendazole yenzeka njengomgubo omhlophe wekristale onganyibilikiyo emanzini.Ukufunxa ngomlomo kwe-albendazoleis kuphuculwe kukutya okunamafutha.Ichiza lihamba ngokukhawuleza kwaye ligqithise i-metabolism yokuqala kwi-sulfoxide, eyona fomu esebenzayo kwiplasma.Ukupheliswa kobomi be-sulfoxide ukusuka kwiiyure ezili-10 ukuya kwezi-15.I-biliaryexcretion ebonakalayo kunye ne-enterohepatic recycling ye-albendazolesulfoxide kwenzeka.I-Albendazole ngokuqhelekileyo inyamezela kakuhle kunyango lwedosi enye yeenematodes zamathumbu.I-highdose, unyango olude olufunekayo kunyango lwe-clonorchiasis orechinococcal lunokubangela iziphumo ezibi ezifana nokudandatheka komnkantsha, ukuphakama kwee-enzymes ze-hepatic, kunye ne-alopecia.
I-Albendazole inomsebenzi omninzi ngokuchasene ne-nematodes yamathumbu kunye ne-cestodes, kunye ne-flukes yesibindi i-Opisthorchis sinensis, i-Opisthorchis viverrini, kunye ne-Clonorchis sinensis.Ikwasetyenziswe ngempumelelo ngokuchasene neGiardia lamblia.I-Albendazole lunyango olusebenzayo lwe-hydatid cyst disease (echinococcosis), ngakumbi xa ihamba kunye ne-praziquantel.Ikwasebenza kakuhle ekunyangeni i-cerebral kunye ne-spinal neurocysticercosis, ngakumbi xa inikwe i-dexamethasone.I-Albendazole iyacetyiswa kunyango lwe-gnathostomiasis.
