I-BETA-NADPH TETRA(CYCLOHEXYLAMMONIUM) I-SALT Cas: 100929-71-3
| Inombolo Yekhathalogu | XD90431 |
| Igama lemveliso | I-BETA-NADPH TETRA(CYCLOHEXYLAMMONIUM) ITYUWA |
| CAS | 100929-71-3 |
| Ifomula yeemolekyuli | C21H30N7O17P3.4[C6H13N] |
| Ubunzima beMolekyuli | 1142.11748 |
| Iinkcukacha zokuGcina | -20 °C |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe |
| Isivavanyi | 99% |
I-NADPH oxidases yintsapho yee-enzymes ezivelisa iintlobo ze-oksijini esebenzayo (ROS).I-NOX1 (i-NADPH oxidase 1) kunye ne-NOX2 oxidases yimithombo emikhulu ye-ROS kwindonga ye-artery kwiimeko ezifana noxinzelelo lwegazi, i-hypercholesterolaemia, isifo sikashukela kunye nokuguga, kwaye ngoko ke zinegalelo elibalulekileyo kuxinzelelo lwe-oxidative, ukungasebenzi kwe-endothelial kunye nokuvuvukala kwe-vascular. ukulungiswa kwemithambo kunye ne-atherogenesis.Kolu Phononongo, siqhubela phambili imbono ethelekisa nokusetyenziswa kwe-antioxidants eqhelekileyo, inhibiting NOX1 kunye ne-NOX2 oxidases yindlela ephezulu yokulwa noxinzelelo lwe-oxidative.Sichaza ngokufutshane ezinye ze-NADPH oxidase inhibitors eziqhelekileyo kunye nezikhulayo.Ukongeza, sigxininisa indima ebalulekileyo ye-NADPH oxidase subunit yokulawula, i-p47phox, kumsebenzi we-vascular NOX1 kunye ne-NOX2 oxidases, kwaye sicebisa ukuba ukuqonda ngcono ukusebenzisana kwayo kweemolekyuli kunokwenza ukuba kuphuhliswe inoveli yeziyobisi ezikhethiweyo ze-isoform ukukhusela. okanye ukunyanga izifo ze-cardiova scular.
