ICarbenicillin Disodium yeTyuwa yeCas: 4800-94-6 89-109% Emhlophe ukuya kumgubo omhlophe
| Inombolo Yekhathalogu | XD90196 |
| Igama lemveliso | Ityuwa yeCarbenicillin disodium |
| CAS | 4800-94-6 |
| Ifomula yeemolekyuli | I-C17H16N2Na2O6S |
| Ubunzima beMolekyuli | 422.3633 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29411000 |
Ukucaciswa kweMveliso
| pH | 5.5 ~ 7.5 |
| Umxholo wamanzi | ≤ 6.0% |
| Ukunyibilika | Isisombululo esicacileyo kunye nesityheli kancinane |
| Isivavanyi | 99% |
| Amandla | 830 ug/mg |
| IiPyrogens | ≤80mg/kg |
| Ugqithiso | Iyahambelana |
| Imbonakalo | Umgubo omhlophe ukuya kumhlophe |
| Izinto zokufunxa iodine | ≤8.0% |
| Ibanga le-Usp | Iyahambelana |
| Uvavanyo (penicillin G) | Iyahambelana |
Ukwenzakala kwesibindi ngenxa yeziyobisi yenye yezona zinto zibangela ukuthotywa kweziyobisi.Ukukwazi ukuqikelela iziphumo zesibindi zabagqatswa bechiza ukusuka kulwakhiwo lweekhemikhali kubalulekile ukunceda ukukhokela iiprojekthi zovavanyo lokufunyanwa kwechiza ukuya kumayeza akhuselekileyo.Kulo cwaningo, siye saqulunqa isethi yedatha ye-951 i-compounds echazwe ukuba ivelise uluhlu olubanzi lweempembelelo kwisibindi kwiintlobo ezahlukeneyo, ezibandakanya abantu, iigundane kunye nee-nonrodents.Iziphumo zesibindi kule seti yedatha zifunyenwe njengemethadatha eqinisekisayo, eveliswe kwi-MEDLINE abstracts usebenzisa indibaniselwano ekhethekileyo yeendlela ze-lexical kunye neelwimi kunye nemithetho ye-ontological.Siye sahlalutya le seti yedatha sisebenzisa iindlela eziqhelekileyo ze-cheminformatics kwaye sajongana nemibuzo emininzi ephathelele kwi-concordance ye-cross-species yeziphumo zesibindi, imichiza yeekhemikhali zeziphumo zesibindi kubantu, kunye nokuqikelelwa ukuba ingaba i-compound enikiweyo inokubangela umphumo wesibindi ebantwini.Sifumene ukuba i-concordance yeziphumo zesibindi yayiphantsi (ca. 39-44%) phakathi kweentlobo ezahlukeneyo, ukuphakamisa ukuba kungenzeka ukuba uhlobo oluthile lwezilwanyana lunokuxhomekeka kwiimpawu ezithile zesakhiwo samakhemikhali.Iikhompawundi zahlanganiswa ngokufana kwazo kweekhemikhali, kwaye iikhompawundi ezifanayo zahlolwa ukufana okulindelekileyo kwiiprofayili zempembelelo yesibindi esixhomekeke kuhlobo.Kwiimeko ezininzi, iiprofayili ezifanayo ziye zajongwa kumalungu eqela elinye, kodwa ezinye iikhompawundi zavela njengangaphandle.Ii-outliers zazingumxholo wokuqinisekiswa okugxininisiweyo kwi-MEDLINE kunye neminye imithombo yedatha.Kwezinye iimeko, uqinisekiso olongezelelweyo lwebhayoloji lwachongwa, oluhambelana nolindelo olusekwe kwimichiza yeekhompawundi ezifanayo.Iinkcazo ziphinde zaguqulelwa kwiinkcazo zokubini zeekhemikhali ezingaphantsi (okt, isiphumo sesibindi vs akukho siphumo sesibindi), kunye neemodeli zebinary quantitative structure-activity relationship (QSAR) zenziwa ukuqikelela ukuba ikhompawundi ilindeleke ukuba ivelise iziphumo zesibindi ebantwini.Nangona kubonakala ukungafani kwedatha, iimodeli zibonise amandla aqikelelweyo ahlolwe yinkqubo yangaphandle ye-5-fold-validation cross-validation.Amandla angaphandle axela kwangaphambili iimodeli ze-QSAR zebinary zaqinisekiswa ngakumbi ngokusetyenziswa kwazo kwii-compounds ezifunyenweyo okanye ezifundwe emva kokuba imodeli iphuhlisiwe.Ngokolwazi lwethu, esi sisifundo sokuqala soqikelelo lwetyhefu lwekhemikhali olusebenzise imodeli ye-QSAR kunye nezinye iindlela ze-cheminformatics kwidatha yokujonga eveliswa ngeendlela zokumbiwa kwesicatshulwa ngokuzenzekela ngokulungiswa okulinganiselweyo, ukuvula amathuba amatsha okuvelisa kunye nokwenza imodeli ye-chemical toxicology. idatha.
