Iimveliso

Ukusebenza kweeathomu ze-antibiotics ekunyangeni i-Pseudomonas aeruginosa pneumonia kuyancipha ngenxa yokusasazwa kokumelana nebhaktheriya.Ubukho beenkqubo zonxibelelwano lwebhaktiriya, ezifana noluvo lwekhoram, bunike amathuba amatsha onyango.IiLactonases zicima ngokufanelekileyo i-acyl-homoserine-based bacterial quorum sensing, ibandakanya ezi enzymes njengamachiza amatsha e-anti-Pseudomonas anokuthi avavanywe kwinyumoniya. Ukusweleka kwempuku ye-P. aeruginosa inyumoniya.Ukuvavanya ukucinywa kwekhoram ye-SsoPox-I-mediated, saqala salinganisa umsebenzi we-virulence gene lasB, i-synthesis ye-pyocianin, umsebenzi we-proteolytic wokunqunyanyiswa kwebhaktiriya kunye nokusekwa kwe-biofilm ye-a. I-PAO1 yoxinzelelo olukhule kubukho be lactonase.Kwimodeli eyingozi kakhulu ye-P. aeruginosa inyumoniya kwiimpuku, sivavanye iziphumo zonyango lwangemva koqhoqhoqho okanye olurhoxisiweyo kunye ne-SsoPox-I kukufa, inani lebhaktiriya emiphungeni kunye nomonakalo wemiphunga. , i-pyocianin synthesis, umsebenzi weproteolytic kunye nokwakheka kwe-biofilm.Ukusetyenziswa kwangoko kwe-SsoPox-I kwanciphisa ukufa kweegundane nge-pneumonia enzima ukusuka kwi-75% ukuya kwi-20%.Umonakalo wemiphunga we-Histological wancitshiswa kakhulu kodwa ubalo lwebhaktiriya emiphungeni aluzange lutshintshwe lunyango.Unyango olulibazisiweyo ludibene nokunciphisa okungabalulekanga kokusweleka.Ezi ziphumo zibonisa iziphumo zokukhusela i-lactonase SsoPox-I kwi-P. aeruginosa pneumonia kwaye ivule indlela yokusetyenziswa kwonyango lwexesha elizayo.