I-PVP-K30 Cas: 9003-39-8 Imhlophe ukuya kumgubo omhlophe otyheli
| Inombolo Yekhathalogu | XD90232 |
| Igama lemveliso | I-PVP-K30 |
| CAS | 9003-39-8 |
| Ifomula yeemolekyuli | C8H15NO |
| Ubunzima beMolekyuli | 141.2108 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 39059990 |
Ukucaciswa kweMveliso
| Amanzi | <5% |
| Iintsimbi ezinzima | <10ppm |
| pH | 3 - 7 |
| Intsalela kwi-Ignition | <0.1% |
| Iialdehydes | 0.05% ubukhulu |
| Nitrogen | 11.5 - 12.8% |
| Imbonakalo | Umgubo omhlophe ukuya kumthubi |
| Ixabiso le-K | 27 - 32.4 |
| IHydrazine | 1.0% ubukhulu |
| Isivavanyi | 99% |
Siye saphanda ukuzinza komzimba we-amorphous curcumin dispersions kunye nendima ye-curcumin-polymer intermolecular interactions ekulibaziseni i-crystallization.I-Curcumin imodeli enomdla imodeli njengoko yenza zombini i-intra kunye ne-intermolecular hydrogen bonds kwi-crystal.Isethi esakhiweyo esahlukileyo se-amorphous dispersion polymers yaphandwa;poly(vinylpyrrolidone), Eudragit E100, carboxymethyl cellulose acetate butyrate, hydroxypropyl methyl cellulose (HPMC) kunye HPMC-acetate succinate.I-spectroscopy ephakathi kwe-infrared yayisetyenziselwa ukumisela kunye nokulinganisa ubungakanani bentsebenziswano ye-curcumin-polymer.Ukuzinza ngokomzimba phantsi kweemeko ezahlukeneyo zokusingqongileyo kwajongwa nge-powder X-ray diffraction.Ukuzinza kweekhemikhali ze-Curcumin kwajongwa yi-UV-Vis spectroscopy.Ukwahlukaniswa kwe-curcumin ye-amorphous ezinzileyo kwakunzima ngokungabikho kweepolymers.Iipolymers zibonise ukuba zisebenza kakuhle i-curcumin crystallization inhibitors eyenza ukuveliswa kwe-amorphous solid dispersions;nangona kunjalo, iipolymers zibonise izakhono ezahlukeneyo kakhulu zokuthintela i-crystallization ngexesha lokugcinwa kwexesha elide.I-Curcumin intramolecular hydrogen bonding yanciphisa ubungakanani be-hydrogen bonding yayo kunye neepolymers;kungoko uninzi lweepolima bezingezizo ii-crystallization inhibitors ezisebenza kakhulu.Ngokubanzi, iipolymers zibonakalise ukuba ziyi-crystallization inhibitors, kodwa inhibition yayilinganiselwe ngenxa ye-intramolecular hydrogen bonding kwi-curcumin, ekhokelela ekunciphiseni ukukwazi kweepolymers ukusebenzisana kwinqanaba le-molecular.
