Iimveliso

I-compound tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2--[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2, I-2-dimethyl-1,3-dioxane-4-acetate i-compound organic compound kunye nezicelo ezinokuthi zifakwe kwiinkalo ezahlukeneyo ezibandakanya amayeza, i-agrochemicals, kunye ne-chemistry yezinto. pyrimidine, kunye neringi yedioxane.Ubukho beqela le-tert-butyl kunye ne-acetate libonisa ukuzinza kunye nokulula kokuphatha.Kwintsimi yamachiza, le khompawundi inokuba namandla njengesixhobo esisebenzayo sonyango (i-API) yokuphuhliswa kwamachiza amatsha.Ubukho beqela le-pyrimidine bucebisa ukusebenzisana okunokwenzeka kunye neethagethi zezinto eziphilayo, okwenza kube ngumviwa oxabisekileyo wokufumana iziyobisi.Iqela le-4-fluorophenyl elifakwe kwi-pyrimidine liyaziwa ngokubaluleka kwayo ekuyilweni kweziyobisi ngenxa yegalelo layo ekubopheni ubudlelwane kunye ne-bioactivity.Inokuthi ikhulise umsebenzi webhayoloji yekhompawundi okanye ukukhetha okujoliswe kuko.Iqela le-ethonyl elikhoyo kwikhompawundi lizisa ulwahlulo olongezelelweyo lwesakhiwo, olunokuba luncedo ekumodareyitheni amandla ekhompawundi, ukusebenza kakuhle, kunye neempawu ze-pharmacokinetic.Amalungu kwiqela le-ethenyl, njengamaqela e-methyl kunye ne-methylsulfonyl amino, aphucula ngakumbi ukuhlukana kweekhemikhali zekhompawundi kwaye anokuba negalelo kwi-bioactivity okanye kwiipropati ezifana neziyobisi.Ukongezelela, i-1,3-dioxane ring moiety iye yabandakanyeka kwizicelo ezahlukeneyo. , kubandakanywa njengesixhasi sokunyibilika okanye njengenkqubo yokuhanjiswa kwezinye iikhompawundi ezisebenzayo.Ubukho bayo kule khompawundi bucebisa ukuba inokuphucula ukunyibilika okanye ukuzinza kwekhompawundi.Ngaphandle kokusetyenziswa kwamachiza, le khompawundi inokufumana izicelo kwiikhemikhali ze-agrochemicals njenge-arhente yokukhusela izityalo.Inokuthi ibonise umsebenzi we-pesticide ngokuchasene nezinambuzane okanye ibe nenye imiphumo enenzuzo ekukhuleni kwezityalo kunye nempilo.Ngaphezu koko, iimpawu zesakhiwo sekhompawundi, ezifana neqela le-tert-butyl kunye neringi ye-dioxane, yenza kube nomtsalane kwizicelo kwi-chemistry yezinto.Ingasebenza njengebhloko yokwakha okanye i-precursor ye-synthesis yezinto zenoveli ezineempawu ezizodwa, ezifana nezixhobo ze-polymeric okanye iikhemikhali ezizodwa. -6-(1-methylethyl) -2- [methyl(methylsulfonyl) amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate yi-compound enezicelo ezinokuthi zenziwe kumachiza, agrochemicals, kunye nekhemistri yemathiriyeli.Ubume bayo beekhemikhali ezizodwa kunye namaqela asebenzayo acebisa ukufaneleka kuphuhliso lwamachiza, ukukhuselwa kwesityalo, okanye ukuhlanganiswa kwezinto ezintsha.Nangona kunjalo, uphando olongezelelweyo luyafuneka ukuhlola ngokupheleleyo i-bioactivity yayo, ukukhetha okujoliswe kuyo, iipropati ze-pharmacokinetic, kunye nokhuseleko ngaphambi kokuba lusetyenziswe kwizicelo ezithile.