IVancomycin hydrochloride Cas: 1404-93-9 Imhlophe iphantse ibemhlophe okanye ibentsundu ukuya kumgubo opinki
| Inombolo Yekhathalogu | XD90197 |
| Igama lemveliso | Vancomycin hydrochloride |
| CAS | 1404-93-9 |
| Ifomula yeemolekyuli | I-C66H76Cl3N9O24 |
| Ubunzima beMolekyuli | 1485.7145 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29419000 |
Ukucaciswa kweMveliso
| Amanzi | NMT 5.0% |
| Iintsimbi ezinzima | NMT 30ppm |
| pH | 2.5 - 4.5 |
| I-endotoxins yebhaktheriya | I-NMT 0.33EU/mg yeVancomycin |
| Ukucaca kwesisombululo | Cacileyo |
| Imbonakalo | Imhlophe, iphantse ibe mhlophe, okanye ibentsundu ukuya kumgubo opinki |
| Vancomycin B | NLT 85% |
| Umda we-monodechlorovancomycin | NMT 4.7% |
| Uvavanyo (microbial, anhydrous basis) | NLT 900ug/mg |
1.Izehlo zosulelo lweStaphylococcus aureus olufunyanwa luluntu olufunyanwa luluntu lukhula ngesantya esothusayo.Unyango olusebenzayo ngokwembali lubandakanya ukutshatyalaliswa kwangaphambili kunye nolawulo lwe-antibiotic.Olu phononongo lwenzelwe ukujonga ngokubonakalayo ukusebenza konyango lwe-empiric ekuphatheni izifo zesandla. Ulingo olulindelekileyo lwenziwa kwinqanaba lesibhedlele sesithili.Izigulana ezinosulelo lwesandla zifumene i-empiric intravenous vancomycin ekumkelweyo okanye nge-intravenous cefazolin.Iziphumo zalandelwa kusetyenziswa ubungqongqo bosulelo, impendulo efanelekileyo yeklinikhi, kunye nobude bokuhlala.Ukusebenza kweendleko kubalwa kusetyenziswa iindleko ezipheleleyo kwisigulane ngasinye kumaqela omabini.Uhlalutyo lwamanani lwenziwa.Izigulane ezingamashumi amane anesithandathu zabhaliswa kwisifundo.Amashumi amabini anesine ayenziwe ngokungaqhelekanga kwi-cefazolin (i-52.2 ekhulwini) kunye ne-22 (i-47.8 ekhulwini) kwi-vancomycin.Kwakungekho umehluko wezibalo phakathi kweendleko zonyango (p <0.20) okanye ubude bexesha lokuhlala (p <0.18) phakathi kwamaqela.Izigulane ezifakwe kwi-cefazolin zineendleko eziphezulu zonyango xa kuthelekiswa nezigulane ezifakwe kwi-vancomycin (p <0.05).Izigulane ezinosulelo olubi kakhulu zineendleko zeendleko zonyango (p <0.0001) kunye nexesha elide lokuhlala (p = 0.0002).Kufutshane nokuphela kophononongo, iziganeko ze-methicillin-resistant S. aureus kwisibhedlele sesithili sababhali zafunyaniswa ukuba zingama-72 ekhulwini, nto leyo eyabangela ukuba uphononongo lupheliswe kwangethuba yibhodi yophononongo yeziko ngenxa yeziganeko eziphezulu. Ukuthintela ukubanjwa kwe-randomization.Unyango olufanelekileyo lwakwangoko lwe-methicillin-resistant S. aureus alukaqinisekiswanga ngokuqinisekileyo.Akukho mahluko kwisiphumo sokusebenzisa i-cefazolin ngokuchasene ne-vancomycin njenge-arhente yomgca wokuqala ichongiwe.
I-2.Ngokuphucula ukuphulukiswa kwesilonda ngokusebenzisa i-intravenous prophylactic antibiotics kunye nokulungiswa kwezobuchwepheshe, ukusuleleka kwe-elbow emva kokuhlinzwa kuye kwaba yinto engavamile kodwa kusenzeka kwiinkqubo ezithile ezikhethiweyo ze-elbow.Injongo yolu phononongo yayikukuvavanya ukhuseleko kunye nokusebenza kakuhle kokusetyenziswa kweprophylactic yevancomycin kwindawo yokusebenza ukunciphisa izehlo zosulelo emva kokukhululwa okuvulekileyo kweengqiniba eziqinileyo zasemva kokwenzakala. ixesha lenziwe.Kwiqela lolawulo (izigulane ze-93), i-prophylaxis elula kunye ne-antibiotics ye-intravenous standard yenziwa;kwiqela le-vancomycin (izigulane ze-179), i-vancomycin powder isetyenziswe ngokuthe ngqo kwilonda ngaphambi kokuvalwa kunye ne-standard intravenous prophylaxis.Emva kokulandelwa ubuncinane kweenyanga ze-6, iqela lokulawula lifunyenwe linesifo se-6 (6.45%; ikhefu: 2.40% -13.52%) xa kuthelekiswa nanye (0%; ixesha lokuzithemba: 0-2% 04%) kwiqela levancom ycin, eyayiyintlukwano ephawulekayo (P = .0027).Akukho miphumo emibi ebhalwe ngokusetyenziswa ngokuthe ngqo kwe-vancomycin powder.Ukusetyenziswa kwendawo ye-vancomycin powder ingaba yindlela ethembisayo yokuthintela ukusuleleka kwe-elbow emva kokukhululwa kwe-elbow kwizigulane ezine-post-traumatic elbow stiffness.
