I-D-Mannitol Cas: 69-65-8 96-101.5% I-crystalline powder emhlophe
| Inombolo Yekhathalogu | XD90226 |
| Igama lemveliso | D-Mannitol |
| CAS | 69-65-8 |
| Ifomula yeemolekyuli | C6H14O6 |
| Ubunzima beMolekyuli | 182.1718 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29054300 |
Ukucaciswa kweMveliso
| Indawo yokunyibilika | 164 - 169 Deg C |
| IBanga | BP |
| Ukujikeleza okuthe ngqo | +23 - +25 |
| AS | <1ppm |
| Ilahleko ekomisweni | <0.3% |
| Sulfate | <0.01% |
| Isivavanyi | 96 - 101.5% |
| Nickel | ≤ 1ppm |
| Iasidi | <0.2ml |
| Ukunciphisa Iswekile | ≤ 0.1% |
| Ukuqhuba | ⩽ 20us/cm |
| Cl | <0.007% |
| Imbonakalo | Umgubo omhlophe wekristale |
Ukuphanda indima yoxinzelelo lwe-oxidative kunye / okanye ukukhubazeka kwe-mitochondrial kwisehlo sokwenzakala okukhulu kwezintso (AKI) ngexesha le-sepsis, senze imodeli ye-sepsis-induced in vitro model usebenzisa iiseli ze-epithelial ze-proximal tubular ezivezwe kwi-endotoxin yebhaktiriya (lipopolysaccharide, LPS).Olu phando lubonelele ngeempawu eziphambili kubudlelwane phakathi koxinzelelo lwe-oxidative kunye neziphene zomsebenzi wekhonkco lokuphefumla le-mitochondrial.Unyango lwe-LPS lubangele ukwanda kwintetho ye-inducible nitric oxide synthase (iNOS) kunye ne-NADPH oxidase 4 (NOX-4), iphakamisa i-cytosolic overexpression ye-nitric oxide kunye ne-superoxide anion, iintlobo ze-nitrogen ezisebenzayo (RNS) kunye neentlobo ze-oxygen ezisebenzayo. (ROS).Le meko ye-oxidant ibonakala ngathi iphazamisa i-phosphorylation ye-mitochondrial oxidative ngokunciphisa umsebenzi we-cytochrome c oxidase.Ngenxa yoko, ukuphazamiseka kuthutho lwe-electron kunye nokumpompa kweproton ngaphaya kwenwebu yangaphakathi ye-mitochondrial kwenzeke, okukhokelela ekunciphiseni kwenwebu ye-mitochond rial, ukukhutshwa kwezinto ezibangela i-apoptotic kunye nokuncipha kwe-adenosine triphosphate.Okubangela umdla kukuba, emva kokujoliswa yi-RNS kunye ne-ROS, i-mitochondria yaba ngumvelisi we-ROS, ngaloo ndlela inegalelo ekonyuseni ukungasebenzi kakuhle kwe-mitochondrial.Indima ye-oxidants kwi-mitochondrial dysfunction yaqinisekiswa ngakumbi ngokusetyenziswa kwe-iNOS inhibitors okanye i-antioxidants egcina umsebenzi we-cytochrome c oxidase kunye nokuthintela ukuchithwa kwe-membrane ye-mitochondrial.Ezi ziphumo zibonisa ukuba i-AKI eyenziwe yi-sepsis ayifanele ithathwe njengokusilela kwesimo samandla kodwa kwakhona njengempendulo edibeneyo, kubandakanywa iziganeko zokubhaliweyo, ukubonakaliswa kwe-ROS, umsebenzi we-mitochondrial kunye nokuqhelaniswa kwe-metabolic njenge-apoptosis.
