I-Blue Cas ngqo: 314-13-6
| Inombolo Yekhathalogu | XD90533 |
| Igama lemveliso | Blue ngqo |
| CAS | 314-13-6 |
| Ifomula yeemolekyuli | I-C34H24N6Na4O14S4 |
| Ubunzima beMolekyuli | 960.81 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 32129000 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omnyama |
| Isivavanyi | 99% |
| Ilahleko ekomisweni | 10% max |
| Ukunyibilika kwi-0.1% emanzini | Isisombululo esiluhlaza esicacileyo |
| Ubude beWavelengh bobuninzi bokufunxa | 605 - 613nm |
| Ukungafumaneki okuthe ngqo (E1% / 1cm) | 800min |
I-Vascular hyperpermeability inegalelo ekuguleni kokuvuvukala.Iindlela zangoku zovavanyo lwe-vivo lokungena okusekwe kwi-extravasation ye-Albumin e-Evans Blue (EB) ebotshwe yi-albumin iyanzima kwaye ihlala iswele ubuntununtunu.Siye saqulunqa inoveli ye-infrared fluorescence (IRF) indlela yokwenza umlinganiselo we-EB-albumin extravasation ukulinganisa ukunyanzeliswa kwemithambo kwiimodeli ze-murine.I-Vascular permeability ebangelwa yi-endotoxaemia yavavanywa kuwo onke amalungu aqinileyo, ingqondo, ulusu kunye ne-peritoneum yi-IRF kunye nomlinganiselo wendabuko osekelwe kwi-EB kwiincindi zethishu.I-Organ IRF inyuke ngokulandelelana ngokunyuka koxinzelelo lwe-EB ye-intravenous (2.5-25 mg / kg).I-Tissue IRF yayinovakalelo ngakumbi ekuqokeleleni kwe-EB xa kuthelekiswa nendlela esekwe kumfunxa.Ngokuhambelanayo, iyantlukwano kwi-vascular permeability kunye ne-EB ye-organ ekuqokeleleni phakathi kweempuku eziphathwe nge-lipopolysaccharide kunye ne-saline-treated yayihlala ibalulekile xa ihlalutywa ngokubhaqa okusekwe kwi-IRF kodwa hayi ngokufunyaniswa okusekwe kwi-absorbent.I-EB yafunyanwa kuwo onke amalungu angama-353 ahlalutywe nge-IRF kodwa kuphela kwi-67% (239/353) yamalungu ahlalutywe ngendlela esekelwe kumfucumfucu, ebonisa ubuntununtunu obuphuculweyo bokubhaqwa kwe-EB kumalungu ane-IRF.Ngokwahlukileyo, i-EB kwi-plasma emva kokulawulwa kwe-EB yalinganiswa ngokulula ngeendlela zombini kunye nokulungelelaniswa okuphezulu phakathi kweendlela ezimbini (n = 116, r2 = 0.86).Ubungakanani bomahluko okhethekileyo we-EB-IRF ngenxa ye-endotoxin yayilungile xa i-IRF ithelekiswa phakathi kweempuku ezihambelana nobunzima, isini, kunye nobudala, kunye nezilungiso ezifanelekileyo zobunzima bomzimba kunye nokugxilwa kweplasma ye-EB.Ngokucacileyo, indlela yokusebenza ye-EB-IRF ishiya amalungu ekhuselekile kwi-histopathology elandelayo.Isishwankathelo, i-EB-IRF yinoveli, enovakalelo kakhulu, ekhawulezayo, kunye nendlela efanelekileyo yokulinganisa ubungakanani be-EB kumalungu angaguqukiyo onyango ngokuchasene nolawulo lweempuku.
