I-Polymyxin B sulfate CAS: 1405-20-5 Umgubo omhlophe
| Inombolo Yekhathalogu | XD90360 |
| Igama lemveliso | Polymyxin B sulfate |
| CAS | 1405-20-5 |
| Ifomula yeemolekyuli | C55H96N16O13 · 2H2SO4 |
| Ubunzima beMolekyuli | 1385.61 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29419000 |
Ukucaciswa kweMveliso
| Ukuqukumbela | Ihambelana ne-USP35 |
| Iintsimbi ezinzima | <20ppm |
| pH | 5-7 |
| Ukuchongwa | Ichromatography yolwelo: iyahambelana |
| Isivavanyi | 99% |
| Imbonakalo | Umgubo omhlophe |
| Ilahleko ekomisweni | <6% |
| Ukunyibilika | Inyibilika ngokukhululekileyo emanzini, inyibilika kancinane kwi-Ethanol |
| Sulfate | 15.5% - 17.5% |
| Ubungakanani beNcam | <30µm |
| Ukujikeleza okuthe ngqo | -78° -90° |
| Phenylalanine | 9.0%-12.0% |
| IiPyrogens | Uyahlangabezana neemfuno |
| Uthuthu olufakwe emanzini | <0.75% |
| Ubalo olusebenzayo lwe-aerobic | <100cfu/g |
| Amandla | > 6500 IU/mg |
I-ExPortal protein secretion organelle kwi-Streptococcus pyogenes yi-anionic phospholipid-equlethe i-membrane microdomain etyetyiswe kwi-Sec translocons kunye ne-postsecretion protein biogenesis.I-Polymyxin B ibophelela kwaye iphazamise ingqibelelo ye-ExPortal, ekhokelela ekukhuselweni okunesiphene kwee-toxins ezininzi.Ukufumana ukuqonda kwizinto eziphembelela umbutho we-ExPortal, isikrini sofuzo saqhutywa ukuze kukhethwe i-polymyxin B-resistant mutants ezenzekelayo ebonisa ingqibelelo ye-ExPortal eyongeziweyo.Ulandelelwano lwejini epheleleyo engama-25 ekwaziyo ukumelana noguquko lutyhilwe ukusuka kwinguqu enye ukuya kwezine kwijenome nganye edityanisiweyo phakathi kweseti engundoqo yamaqela ali-10 emfuza.Ukwakhiwa kwezinto eziguqukayo ngokucinywa komntu ngamnye okanye ukufakwa kubonise ukuba i-7 yemfuza engundoqo inika ukuxhathisa kunye nokuphucula imfezeko ye-ExPortal ngokulahleka komsebenzi, ngelixa i-3 inokwenzeka ngenxa yenzuzo yokusebenza kunye / okanye imiphumo edibeneyo.Izakhi zofuzo ezingundoqo zibandakanya i-transcriptal regulator ye-lipid biosynthesis, iindidi ezininzi ezibandakanyekayo ekufumaneni izondlo, kunye neentlobo ezahlukeneyo ezibandakanyekayo kwiimpendulo zoxinzelelo.Amalungu amabini odidi lokugqibela asebenza njengabalawuli abanoveli be-SpeB eyimfihlo ye-cysteine protease.Uhlalutyo lwenguqu ehlala ihleli yodwa, ukucinywa kwe-nucleotide enye kwindlela ye-9 elandelelanayo ye-adenine eseleyo kwi-pstS, i-encoding icandelo le-Pi transporter ephezulu, iphakamisa ukuba olu landelelwano lusebenza njengenguqu ye-molecular ukwenzela ukuba kube lula ukulungiswa koxinzelelo.Ngokudibeneyo, ezi datha zibonisa ubukho bempendulo yoxinzelelo lwe-membrane ekhuthaza ingqibelelo ephuculweyo ye-ExPortal kunye nokuchasana ne-cationic antimicrobial peptides.
