Fluorescein 5-Isothiocyanate (isomer I) CAS:3326-32-7
| Inombolo Yekhathalogu | XD90514 |
| Igama lemveliso | I-Fluorescein 5-Isothiocyanate (isomeri I) |
| CAS | 3326-32-7 |
| Ifomula yeemolekyuli | I-C21H11NO5S |
| Ubunzima beMolekyuli | 389.38 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 32129000 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo otyheli okhanyayo |
| Isivavanyi | 99% |
I-Ischemic stroke ibonakaliswe ukuba ibangele i-hypermetabolism ye-glucose kwi-ischemic penumbra.Idatha yovavanyo kunye nekliniki ibonisa ukuba i-infarct-related systemic hyperglycemia yinto ekujoliswe kuyo yonyango kwi-stroke ebukhali.Nangona kunjalo, izifundo zeklinikhi ezijolise kulawulo lwe-glucose kwi-stroke ebukhali azizange ziphucule iziphumo zokusebenza okanye zinciphise ukufa.Ngaloo ndlela, uphando olongezelelweyo kwi-glucose metabolism kwingqondo ye-ischemic iqinisekisiwe.Sisebenzise imodeli yegundane ye-stroke egcina ukuhamba kwe-collateral.Izilwanyana zahlalutya nge- [2- (18) F] -2-fluoro-2-deoxy-d-glucose positron emission tomography okanye imaging resonance magnetic ngexesha le-90-minute occlusion of the middle cerebral artery and during 60 minutes after reperfusion.Iziphumo zinxulunyaniswa ne-imaging resonance magnetic of cerebral blood flow, ukusasazwa kwamanzi, ukubunjwa kwe-lactate, kunye nedatha ye-histological yokufa kweeseli kunye nokuphazamiseka komqobo wegazi-ubuchopho. -i-deoxy-d-glucose efunyenwe ngaphakathi kwi-ischemic re gions enikezela kwi-infarction nakwingingqi ye-peri-infarct.I-imaging resonance imaging ibonakalise ukonakala kokuhamba kwegazi ukuya kumanqanaba e-ischemic kwi-infarct kunye nokunciphisa ukuhamba kwegazi kwi-cerebral kwingingqi ye-peri-infarct.I-Magnetic resonance spectroscopy ibonise i-lactate kwingingqi ye-ischemic kunye nokungabikho kwelactate kummandla we-peri-infarct.Uhlalutyo lwe-Immunohistochemical luveze i-apoptosis kunye ne-blood-brain barrier breakdown ngaphakathi kwe-infarct.Ukunyuka kokunyuka kwe- [2-(18)F]-2-fluoro-2-deoxy-d-glucose kwi-cerebral ischemia eyona nto ibonakalisa i-hypermetabolism yentlanganiso ye-glucose eyandisiweyo yamandla. iimfuno ze-ischemic kunye ne-hypoperfused brain tissue, kwaye yenzeka phantsi kweemeko zombini ze-anaerobic kunye ne-aerobic ezilinganiswe ngemveliso ye-lactate yendawo.I-hyperglycemia enxulumene ne-infarct inokusebenza lula ukubonelelwa kweglucose kwingqondo ye-ischemic.Ulawulo lweGlycemic ngonyango lwe-insulin lunokuba nefuthe elibi kule ndlela.
