I-GSSG Cas: 27025-41-8 I-crystalline powder emhlophe
| Inombolo Yekhathalogu | XD90229 |
| Igama lemveliso | GSSG |
| CAS | 27025-41-8 |
| Ifomula yeemolekyuli | I-C20H32N6O12S2 |
| Ubunzima beMolekyuli | 612.631 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 2930909899 |
Ukucaciswa kweMveliso
| Ukujikeleza okuthe ngqo | -96 ukuya -106 |
| Iintsimbi ezinzima | 10ppm ubukhulu |
| AS | 2ppm ubukhulu |
| Ilahleko ekomisweni | 15.0% ubukhulu. |
| Ubunyulu | 95% imizuzu |
| Intsalela kwi-Ignition | 0.5% ubukhulu |
| Imbonakalo | Umgubo omhlophe wekristale |
| Isivavanyi | 99% |
I-Hepatotoxicity yabaviwa beziyobisi yenye yezona zinto zixhalabisayo ekuhlolweni kweziyobisi ekuqaleni kokufunyanwa kweziyobisi.Ukufunyanwa koxinzelelo lwe-hepatic oxidative kunokuba sisalathisi sokuqala se-hepatotoxicity kunye neenzuzo zokukhetha amachiza.I-glutathione (GSH) kunye ne-glutathione disulfide (GSSG) ibini, njengenye yezona zinto zibalulekileyo ze-intracellular redox ezilawula izibini, zidlala indima ebalulekileyo ekukhuseleni iiseli kuxinzelelo lwe-oxidative olubangelwa ukungalingani phakathi kwe-prooxidants kunye ne-antioxidants.Ukumiselwa kobungakanani be-GSSG / GSH ratios kunye nokugxilwa kwe-GSH kunye ne-GSSG kusetyenziswe ukubonisa uxinzelelo lwe-oxidative kwiiseli kunye nezicubu.Kolu phononongo, sivavanye ithuba lokusebenzisa i-biliary GSSG/GSH ratios njenge-biomarker ukubonisa uxinzelelo lwe-hepatic oxidative kunye netyhefu yeziyobisi.Iikhompawundi ezine ezaziwa ngokutshintsha amanqanaba e-GSH kunye ne-GSSG ziye zavavanywa kolu phononongo.I-Diquat (i-diquat dibromide monohydrate) kunye ne-acetaminophen zalawulwa kwiigundane.I-Paraquat kunye ne-tert-butyl hydroperoxide zilawulwa d kwiigundane ukuze zenze utshintsho lwe-biliary GSH kunye ne-GSSG.I-GSH ye-biliary kunye ne-GSSG zilinganiswe ngokusebenzisa ii-curves zokulinganisa ezilungiselelwe nge-bile yokufakelwa ukuhlawula nayiphi na impembelelo ye-bile matrix kuhlalutyo lwe-LC-MS kunye nokuphepha ukuphazamiseka kwe-GSH engapheliyo kunye ne-GSSG.Ngemizekelo emine (kwiigundane kunye neempuku) yeenguqu ezibangelwa ngamachiza kwi-kinetics ye-biliary GSSG / GSH ratios, olu pho nonongo lubonise amandla okuphuhlisa i-index exposure response index esekelwe kwi-biliary GSSG / GSH ratios yokuqikelela uxinzelelo lwe-hepatic oxidative.
