I-Streptozocin CAS: 18883-66-4 I-crystalline powder ePale
| Inombolo Yekhathalogu | XD90359 |
| Igama lemveliso | streptozocin |
| CAS | 18883-66-4 |
| Ifomula yeemolekyuli | I-C8H15N3O7 |
| Ubunzima beMolekyuli | 265.22 |
| Iinkcukacha zokuGcina | -20 °C |
| IKhowudi yoMrhumo eHarmonized | 29419090 |
Ukucaciswa kweMveliso
| Isivavanyi | 99% |
| Imbonakalo | Umgubo wekristale omthubi |
Isifo seswekile sinxulumene nenqanaba elisezantsi lokudumba okungapheliyo kunye noxinzelelo lwe-oxidative.I-Bupleurum Polysaccharides (BPs), eyodwa kwi-Bupleurum smithii var.I-parvifolium ine-anti-inflammatory kunye ne-anti-oxidative properties.Nangona kunjalo, kuncinci okwaziwayo malunga nemiphumo yonyango kwisifo seswekile.Kolu vavanyo, iziphumo ze-BPs ekunciphiseni isifo sikashukela kunye neendlela ezisisiseko zaphandwa.Imodeli yeempuku zesifo seswekile yasekwa ngeenaliti ezilandelelanayo ze-intraperitoneal ze-streptozotocin (100 mg/kg ubunzima bomzimba) iintsuku ezimbini.Iigundane ezinamazinga eglucose yegazi ngaphezulu kwe-16.8mmol / L zikhethwe kwiimvavanyo.Iigundane zesifo sikashukela zilawulwa ngomlomo nge-BPs (30 kunye ne-60 mg / kg) kanye ngosuku ngeentsuku ze-35.I-BPs ayizange inciphise kakhulu amanqanaba e-glucose yegazi, kodwa yandisa i-insulin ye-serum kunye ne-glycogen yesibindi kwiigundane zesifo sikashukela xa kuthelekiswa neempuku zemodeli.Ukongeza, ulawulo lwe-BPs luphucule ukubonakaliswa kwe-insulin kwaye lwacinezela i-apoptosis kwi-pancreas yeempuku zeswekile.Uphononongo lwe-Histopathological lubonise ngakumbi ukuba ii-BPs zikhusela i-pancreas kunye nesibindi kumonakalo owenziwe nge-oxidative kunye nokudumba.Ezi ziphumo zibonisa ukuba i-BPs ikhusela iiseli ze-pancreatic β kunye ne-hepatocytes yesibindi kunye ne-ameliorate diabetes, ehambelana ne-anti-oxidative kunye ne-anti-inflammatory properties.
