I-Cytochrome C CAS: 9007-43-6 Umgubo obomvu obomvu okanye omnyama
| Inombolo Yekhathalogu | XD90330 |
| Igama lemveliso | I-Cytochrome C |
| CAS | 9007-43-6 |
| Ifomula yeemolekyuli | I-C42H54FeN8O6S2 |
| Ubunzima beMolekyuli | 886.91 |
| Iinkcukacha zokuGcina | -15 ukuya -20 °C |
| IKhowudi yoMrhumo eHarmonized | 35040090 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo obomvu okanye omnyama omnyama |
| Isivavanyi | 99% |
| pH | 5 - 7 |
| Intsimbi | 0.40 - 0.48% |
| Ubunyulu | Ubuncinci 90% |
| Intsalela kwi-Ignition | Ubuninzi 1.5% |
| Ukufuma | Ubukhulu 6% |
| Ubuzali | Iyahambelana novavanyo lobudlolo |
| IiPyrogens | Mahala |
| Uvavanyo lombala | Okuhle |
| E. Coli | Ukungabikho |
| Iintlobo zeSalmonella | Ukungabikho |
| Ukunyibilika 10% emanzini | Sula ngombala obomvu |
| Ixabiso lokuphela | Er/Eo:Min1.1 |
| Ubalo lweMicrobial iyonke cfu / g | Ubukhulu be-100 |
| Umngundo/Igwele | Ukungabikho |
| Imvelaphi | Intliziyo yehashe |
Uncwadi oluvelayo lubonisa ukuba i-bisphenol A (BPA), i-endocrine ephazamisayo ikhemikhali exhaphakileyo, xa ukuvezwa kwenzeka ebomini bokuqala, kunokunyusa umngcipheko we-metabolic syndrome.Kolu phononongo, siphande i-hypothesis yokuba ukuvezwa kwe-perinatal kwi-BPA kulungiselelwe inzala kwisifo sesibindi esinamafutha: ukubonakaliswa kwe-hepatic ye-metabolic syndrome, kunye nendlela enokwenzeka ngayo.Iigundane zeWistar ezikhulelweyo zilawulwa nge-BPA (40μg/kg/day) okanye isithuthi ngexesha lokumitha nokuncancisa.I-histology yesibindi, uhlalutyo lwe-biochemical, i-transcriptome, kunye nomsebenzi we-mitochondrial zihlolwe kwinzala yamadoda emva kokubeleka kwe-3, i-15 kunye neeveki ze-26.Kwiiveki ze-3 ubudala, i-morphology engaqhelekanga yesibindi kunye nomsebenzi awuzange ubonwe kwi-BPA-evezwe inzala, kodwa ukuncipha kwe-mitochondrial breathing complex (MRC) umsebenzi (I kunye ne-III) kunye noshintsho olubalulekileyo kwi-gene expression echaphazelekayo kwi-mitochondrial fatty acid metabolism. iqwalaselwe xa kuthelekiswa nolawulo.Kwiiveki ze-15, i-micro-vesicular steatosis kwisibindi, i-up-regulated genes ebandakanyekayo kwiindlela ze-lipogenesis, i-ROS isizukulwana kunye nokukhululwa kwe-Cytc kwabonwa kwi-BPA-evezwe inzala.Emva koko, ukuqokelela okukhulu kwamafutha kwisibindi kunye ne-serum ephakamileyo ye-ALT yabonwa kwi-BPA-evezwe inzala kwiiveki ze-26.Kwi-longitudinal observation, umsebenzi we-hepatic mitochondrial kuquka umsebenzi we-MRC, ukuveliswa kwe-ATP, ukuveliswa kwe-ROS kunye ne-membrane ye-mitochondrial enokuthi ibe mbi kakhulu kwinzala evezwe yi-BPA.I-Perinatal BPA exposure inegalelo ekuphuhliseni i-hepatic steatosis kwinzala yeempuku, ezinokuthi zixutywe ngokungasebenzi kakuhle kwe-hepatic mitochondrial kunye ne-up-regulated hepatic lipid metabolism.
